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公开(公告)号：US09606245B1
公开(公告)日：2017-03-28
申请号：US15080073
申请日：2016-03-24
Applicant: The Research Foundation for The State University of New York , The Research Foundation for The State University of New York , Memorial Sloan Kettering Cancer Center , Cornell University , University of South Carolina
Inventor： Steve Czarnecki , Andrzej Krol , Krishna Mandal , Mark D. Poliks , C. Ross Schmidtlein , Michael Thompson , James Turner
IPC: G01T1/20
CPC classification number: G01T1/208 , A61B6/037 , A61B6/501 , G01T1/1642 , G01T1/2006 , G01T1/2018 , G01T1/245
Abstract: A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.
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公开(公告)号：US09835737B1
公开(公告)日：2017-12-05
申请号：US15468968
申请日：2017-03-24
Applicant: The Research Foundation for The State University of New York , The Research Foundation for The State University of New York , Memorial Sloan Kettering Cancer Center , Cornell University , University of South Carolina
Inventor： Steve Czarnecki , Andrzej Krol , Krishna Mandal , Mark D. Poliks , C. Ross Schmidtlein , Michael Thompson , James Turner
CPC classification number: G01T1/208 , A61B6/037 , A61B6/501 , G01T1/1642 , G01T1/2006 , G01T1/2018 , G01T1/245
Abstract: A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.
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公开(公告)号：US20250127415A1
公开(公告)日：2025-04-24
申请号：US18920713
申请日：2024-10-18
Inventor： Gary Saulnier , Omid Rajabi Shishvan , Ahmed Abdelwahab
IPC: A61B5/0536
Abstract: A system and method for minimizing signal interference in coaxial cables carrying signals for electrical impedance tomography (EIT) by compensating for losses from both the series and shunt elements on the path from the source to the load, providing a compensated load current and voltage. One or a series of two-port networks is used to modify a current source with applied current to compensate for losses in the cable to attain the desired load current. The input current is adjusted using the measured voltage and the shunting output and stray impedance, preferably determined during a calibration process.
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公开(公告)号：US12257326B2
公开(公告)日：2025-03-25
申请号：US17018314
申请日：2020-09-11
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventor： Jose Manuel Mejia Oneto , Maksim Royzen
IPC: A61K51/06 , A61K31/43 , A61K31/7076 , A61K38/12 , A61K38/14 , A61K47/54 , A61K47/61 , A61K47/66 , A61K47/69 , A61K49/00 , A61K51/04 , A61K51/12 , C07D257/08 , C07D311/82 , C07D499/74 , C07H7/02 , C07H15/24 , C07H19/167 , C07H19/213
Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
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公开(公告)号：US12213820B2
公开(公告)日：2025-02-04
申请号：US17790088
申请日：2021-01-15
Inventor： Andrew Labella , Amirhossein Goldan , Wei Zhao , Eric Petersen
Abstract: The disclosure is directed to a device that includes a cavity formed by a plurality of rails, the plurality of rails connected to both a first support and a second support, each at predetermined intervals about a circumference of the first support and the second support; and at least one particle detection device operably connected to each rail of the plurality of rails. The disclosure is also directed to a scanner that includes the device, and a processor.
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Patent Agency Ranking
公开(公告)号：US20250019264A1
公开(公告)日：2025-01-16
申请号：US18891727
申请日：2024-09-20
Inventor： Benjamin S. HSIAO , Priyanka SHARMA , Sunil Kumar SHARMA , Ken I. JOHNSON
IPC: C02F1/28 , B01J20/24 , B01J20/28 , C02F101/16 , C05F7/00
Abstract: A method of treating contaminated water, such as wastewater, with carboxylated cellulose to remove ammonium and nitrogen-containing impurities is claimed. Carboxylated cellulose extracted by nitro-oxidation has negatively-charged functionality and forms an aggregate when exposed to positively-charged impurities in contaminated water. The aggregate, nitrogen-containing impurities, and by-products from the nitro-oxidation process can be isolated to provide a fertilizer or fertilizer component.
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公开(公告)号：US12186428B2
公开(公告)日：2025-01-07
申请号：US17986430
申请日：2022-11-14
Applicant: TargaGenix, Inc. , The Research Foundation for the State University New York , Northeastern University
Inventor： James E. Egan , Mansoor M. Amiji , Iwao Ojima
IPC: A61K9/107 , A61K31/337 , A61K39/00 , A61K39/395 , A61K47/44 , A61K47/54 , A61P35/00 , C07K16/28
Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
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公开(公告)号：US20250003909A1
公开(公告)日：2025-01-02
申请号：US18625659
申请日：2024-04-03
Inventor： Chuan-Jian Zhong , Shuxia Lu , Guojun Shang , Shan Yan , Jin Luo , Dong Dinh
IPC: G01N27/12 , G01N33/497
Abstract: Air sampling sensor and system for detecting volatile organic compounds and applications thereof. A nanoparticle-structured chemiresistive sensor array in the analyzer generates an output signal based on the presence of selected volatile organic compounds in an air sample. The sensors of the array include sensing films from the group of molecularly-linked gold nanoparticles with different linking and capping molecules and gold nanoparticles of different sizes. A micro-processing unit analyzes the output signal of the sensor array and indicates the presence or absence of selected volatile organic compounds. The air sampling system can be used to analyze human breath and report the presence of volatile organic compounds relevant to lung cancer biomarkers. The air sampling system can also be used as an environmental air monitoring system to detect the presence of hazardous chemicals in the air.
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公开(公告)号：US12178524B2
公开(公告)日：2024-12-31
申请号：US18180257
申请日：2023-03-08
Inventor： Fazel Khan , Michael Bielski , Jafar Khan , Imin Kao , Guangyu He
Abstract: A surgical system is provided. The surgical system includes a camera operable to capture images and/or video. A projector is operable to project light, and a controller is communicatively coupled with the camera and the projector. The controller is operable to track movement of bone in real-time during surgery based on the images and/or video captured by the camera, and control the projector to project the light including a cutting line on the bone to indicate a cutting plane for cutting the bone during surgery.
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公开(公告)号：US20240390975A1
公开(公告)日：2024-11-28
申请号：US18669761
申请日：2024-05-21
Inventor： Scott N. Schiffres , Arad Azizi
Abstract: Additively manufactured non-metal particle and metal matrix composites are provided. An intermetallic compound interface layer, e.g., metal carbide, is formed between the non-metal particle, e.g., diamond, and the metal matrix, that enhances thermal transfer. One application of this is to form thermal management structures with high thermal conductivity via laser powder bed fusion. A powder material for additively manufacturing a structure, comprising metal particles; and non-metallic particles with thermal conductivities greater than 100 W/m-K and coefficient of thermal expansion less than 10 ppm/degree C., wherein the metal particles are fusible with heat to form a heterogeneous solid structure around the non-metallic particles with an intermetallic compound interface, the heterogeneous solid structure having enhanced thermal conductivity and lower coefficient of thermal expansion with respect to a homogeneous specimen of the fused metal particles alone.
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