公开(公告)号：US20140322278A1

公开(公告)日：2014-10-30

申请号：US14126629

申请日：2012-06-19

申请人： Thomas DiRaimondo ,  Xi Jin ,  Cornelius Kloeck ,  Chaitan Khosla

发明人： Thomas DiRaimondo ,  Xi Jin ,  Cornelius Kloeck ,  Chaitan Khosla

IPC分类号： A61K31/5377 ,  A61K31/428 ,  A61K31/423 ,  A61K31/4184

CPC分类号： A61K31/5377 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/473

摘要： Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides.

摘要翻译： 提供组成和方法用于调节组织转谷氨酰胺酶（TG2）的生理活化; 哪些方法可以包括抑制与肠炎性疾病相关的TG2的活化，所述疾病可包括乳糜泻，肠易激综合征，克罗恩病，疱疹样疱疹等。 在本发明的其它实施方案中，提供了用于减少肠组织中不期望的细胞旁转运的方法，特别是大于约500mw的分子的细胞旁转运，例如， 肽，包括但不限于免疫原性麸质肽。