公开(公告)号：US20060132804A1

公开(公告)日：2006-06-22

申请号：US11018994

申请日：2004-12-21

申请人： Marc Dubois ,  Thomas Drake ,  Pavel Fomitchov

发明人： Marc Dubois ,  Thomas Drake ,  Pavel Fomitchov

IPC分类号： G01B11/14

CPC分类号： G01N21/474 ,  G01N21/1702 ,  G01N29/2418

摘要： The present invention provides a compact optical probe assembly that measures ultrasound in materials. The probe uses angle-terminated optical fiber to direct illumination laser light at the surface of a remote target. Ultrasonic displacements at the surface scatter the illumination laser light. Angle-terminated optical fibers collect phase modulated light and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic surface displacements. The probe may also incorporate angle-terminated optical fibers to direct generation laser light to the surface of a remote target to generate ultrasonic surface displacements. Optional shared beam forming element(s) may optically act on the illumination laser and collected phase modulated light.

公开(公告)号：US20050231735A1

公开(公告)日：2005-10-20

申请号：US10828068

申请日：2004-04-20

申请人： Mark Dubois ,  John Deaton ,  Thomas Drake

发明人： Mark Dubois ,  John Deaton ,  Thomas Drake

IPC分类号： G01N29/24 ,  G01N29/34 ,  G01B11/14

CPC分类号： G01N29/2418 ,  G01N29/348 ,  G01N2291/0421

摘要： A system and method that replaces safety requirements of a laser detection system by shifting the wavelength of a detection laser. An optical wavelength converter that shifts the optical wavelength of a detection laser from a first wavelength within the Infrared “A” portion of the spectrum to a more eye-safe wavelength. The detection laser is directed to the surface of a remote target. Ultrasonic displacements at the surface scatter the filtered detection laser. Collection optics then gather phase modulated light scattered by the surface and direct the phase modulated light to an optical processor that produces a signal representative of the ultrasonic displacements. Signal processors then determine the internal structure of the remote target based on the signal.

摘要翻译： 通过移动检测激光器的波长来代替激光检测系统的安全要求的系统和方法。 一种光学波长转换器，其将检测激光器的光波长从光谱的红外“A”部分内的第一波长移位到更安全的波长。 检测激光器被引导到远程目标的表面。 表面上的超声波位移散射了滤波的检测激光。 收集光学器件然后收集由表面散射的相位调制光，并将相位调制光引导到产生表示超声波位移的信号的光学处理器。 然后，信号处理器根据信号确定远程目标的内部结构。

公开(公告)号：US20100056524A1

公开(公告)日：2010-03-04

申请号：US12384477

申请日：2009-04-02

申请人： Edward Giles Mciver ,  Justin Stephen Bryans ,  Ela Smiljanic ,  Stephen John Lewis ,  Joanne Hough ,  Thomas Drake

发明人： Edward Giles Mciver ,  Justin Stephen Bryans ,  Ela Smiljanic ,  Stephen John Lewis ,  Joanne Hough ,  Thomas Drake

IPC分类号： A61K31/5377 ,  C07D239/02 ,  C07D403/12 ,  C07D413/12 ,  A61K31/505 ,  A61K31/506

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D471/04

摘要： A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: R1 is C3-8-cycloalkyl; X is O, NR7 or C3-6-heterocycloalkyl; R2 is aryl, heteroaryl, fused or unfused aryl-C3-6-heterocycloalkyl or fused or unfused heteroaryl-C3-6-heterocycloalkyl, each of which is optionally substituted by one or more substitutents selected from aryl, heteroaryl, C1-6-alkyl, C3-7-cycloalkyl and a group A, wherein said C1-6-alkyl group is optionally substituted by one or more substituents selected from aryl, heteroaryl, R10 and a group A, said heteroaryl group is optionally substituted by one or more R10 groups; and wherein said C3-6-heterocycloalkyl group optionally contains one or more groups selected from oxygen, sulfur, nitrogen and CO; R3 is C1-6-alkyl optionally substituted by one or more substituents selected from aryl, heteroaryl, —NR4R5, —OR6, —NR7(CO)R6, —NR7(CO)NR4R5, —NR7SO2R6, —NR7COOR7, —CONR4R5, C3-6-heterocycloalkyl and wherein R4-7 and A are as defined in the claims.Further aspects relate to the use of said compounds in the treatment of various therapeutic disorders, and more particularly as inhibitors of one or more kinases.

摘要翻译： 本发明的第一方面涉及式（I）化合物或其药学上可接受的盐或酯，其中：R 1为C 3-8 - 环烷基; X是O，NR 7或C 3-6 - 杂环烷基; R 2是芳基，杂芳基，稠合或未稠合的芳基-C 3-6 - 杂环烷基或稠合或未稠合的杂芳基-C 3-6 - 杂环烷基，其各自任选被一个或多个选自芳基，杂芳基，C 1-6 - 烷基 C 3-7 - 环烷基和基团A，其中所述C 1-6 - 烷基任选被一个或多个选自芳基，杂芳基，R 10和A基团的取代基取代，所述杂芳基任选地被一个或多个R 10 团体 并且其中所述C 3-6杂环烷基任选地含有一个或多个选自氧，硫，氮和CO的基团; R 3是任选被一个或多个选自芳基，杂芳基，-NR 4 R 5，-OR 6，-NR 7（CO）R 6，-NR 7（CO）NR 4 R 5，-NR 7 SO 2 R 6，-NR 7 COOR 7，-CONR 4 R 5，C 3 -6-杂环烷基，其中R 4-7和A如权利要求中所定义。 其它方面涉及所述化合物在治疗各种治疗性疾病中的用途，更具体地涉及一种或多种激酶的抑制剂。

公开(公告)号：US20070280677A1

公开(公告)日：2007-12-06

申请号：US11443391

申请日：2006-05-30

申请人： Marc Thomas Drake ,  Tony Dowdell

发明人： Marc Thomas Drake ,  Tony Dowdell

IPC分类号： G03B19/00

CPC分类号： G03B29/00 ,  G02B7/02 ,  G02B15/10

摘要： An auxiliary photographic lens and lens holder bracket for an existing portable cellular phone having a camera function therein. The square U-shaped lens holder bracket straddles the body of the cellular phone positioning the auxiliary lens over the built-in camera lens of the existing cellular telephone. The lens cylinder has a threaded end which screws into a threaded opening in the front of the bracket and against the cell phone case around the built-in lens to secure the lens to the cell phone. The lens holder alternately serves as a protective storage device for the lens when it is not in use with the lens cylinder screwed into the cross piece of the bracket. The lens may be a telephoto lens, a wide angle lens, a filter, or alternately a zoom or adjustable lens.

摘要翻译： 一种用于其中具有照相机功能的现有便携式蜂窝电话的辅助摄影镜头和镜头支架支架。 方形的U形透镜架支架跨越蜂窝电话的主体，将辅助镜头定位在现有蜂窝电话的内置相机镜头上。 透镜圆柱体具有螺纹端部，螺纹端部螺钉到支架前部的螺纹开口并且靠在内置透镜周围的手机壳体上，以将透镜固定到手机。 当透镜架不用于拧入支架的十字架的透镜筒时，透镜架交替地用作透镜的保护存储装置。 透镜可以是远摄镜头，广角镜头，过滤器，或者可选的变焦或可调透镜。

公开(公告)号：US711400A

公开(公告)日：1902-10-14

申请号：US1902109020

申请日：1902-05-26

申请人： HOLLICK THOMAS DRAKE

发明人： HOLLICK THOMAS DRAKE

CPC分类号： B66C21/00

公开(公告)号：US20230150295A1

公开(公告)日：2023-05-18

申请号：US17524921

申请日：2021-11-12

申请人： Jeremy Thomas Drake

发明人： Jeremy Thomas Drake

IPC分类号： B43L1/08 ,  B43L1/10 ,  B43L21/00

CPC分类号： B43L1/08 ,  B43L1/10 ,  B43L21/00

摘要： A reusable chalkboard kit is disclosed. The kit includes a deformable vinyl substrate, an underlayment layer configured to allow the deformable vinyl substrate to frictionally engage a stabilizing surface, at least one writing implement, and an eraser component configured to remove one or more markings generated by the at least one writing implement. The deformable vinyl substrate further includes an extended configuration to support marking/drawing on the deformable vinyl substrate and a storage configuration to support stowing of the kit.

公开(公告)号：US20060215174A1

公开(公告)日：2006-09-28

申请号：US11089902

申请日：2005-03-25

申请人： Marc Dubois ,  Thomas Drake

发明人： Marc Dubois ,  Thomas Drake

IPC分类号： G01B11/02

CPC分类号： G01N21/1717 ,  G01H9/00 ,  G01N29/2418 ,  G01N2291/0423 ,  G01N2291/0425 ,  G01N2291/044

摘要： The present invention provides a method to detect and generate ultrasonic displacements at a remote target for ultrasonic inspection. This method involves generating an ultrasonic wave at a first location on an upper surface of the remote target. This ultrasonic wave is reflected from interior surfaces within the remote target wherein the reflected ultrasonic wave produces ultrasonic displacement at a second location on the upper surface of the remote target. A detection laser beam is generated and directed to the second location on the upper surface of the remote target. Here, the detection laser beam is scattered by the ultrasonic displacements to produce phase-modulated light. This phase-modulated light is collected and processed to obtain data representative of the ultrasonic surface displacements. Further, these ultrasonic displacements, when processed, will yield inspection information associated with the interior of the remote target.

摘要翻译： 本发明提供一种在超声波检查的远程目标处检测和产生超声波位移的方法。 该方法涉及在远程目标的上表面上的第一位置处产生超声波。 该超声波从远程目标内的内表面反射，其中反射的超声波在远程目标的上表面上的第二位置处产生超声波位移。 生成检测激光束并将其引导到远程目标的上表面上的第二位置。 这里，检测激光束被超声波位移散射以产生相位调制光。 收集并处理该相位调制光以获得代表超声表面位移的数据。 此外，这些超声波位移在被处理时将产生与远程目标的内部相关联的检查信息。

公开(公告)号：US20050099634A1

公开(公告)日：2005-05-12

申请号：US10703655

申请日：2003-11-07

申请人： Marc Dubois ,  Kent Burr ,  Thomas Drake ,  Peter Lorraine

发明人： Marc Dubois ,  Kent Burr ,  Thomas Drake ,  Peter Lorraine

IPC分类号： G01B9/02 ,  G01H9/00

CPC分类号： G01H9/00

摘要： The present invention provides an optical filter assembly that reduces the phase and amplitude noise of a detection laser used to detect ultrasonic displacements. The filtered detection laser is directed to the surface of a remote target. Ultrasonic displacements at the surface scatter the filtered detection laser. Collection optics then gather phase modulated light scattered by the surface and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic displacements with an improved SNR. Additional processors may determine the structure of the remote target.

摘要翻译： 本发明提供一种滤光器组件，其减少用于检测超声波位移的检测激光器的相位和幅度噪声。 滤波的检测激光器被引导到远程目标的表面。 表面上的超声波位移散射了滤波的检测激光。 收集光学器件然后收集由表面散射的相位调制光，并将相位调制光引导到光学处理器以产生表示具有改善的SNR的超声波位移的信号。 附加处理器可以确定远程目标的结构。