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1.发明授权Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same 有权融合蛋白的小分子疏水标记及其诱导的降解公开(公告)号：US09500653B2
公开(公告)日：2016-11-22
申请号：US13992076
申请日：2011-12-06
IPC分类号： G01N33/573 , A61K47/48 , C07K1/13 , C12N9/14 , G01N33/50
CPC分类号： G01N33/573 , A61K47/48015 , A61K47/52 , C07K1/13 , C07K2319/20 , C07K2319/95 , C12N9/14 , G01N33/5008 , G01N2500/10
摘要： The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.
摘要翻译： 本发明包括可用于扰乱或破坏跨膜或细胞内蛋白质的功能的化合物，由此化合物与跨膜或细胞内蛋白质的结合诱导跨膜或细胞内蛋白质的蛋白酶体降解。 本发明还包括诱导跨膜或细胞内蛋白质的蛋白酶体降解的方法。 本发明还包括鉴定或验证感兴趣的蛋白质作为治疗疾病状态或病症的治疗靶标的方法。
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公开(公告)号：US20070040351A1
公开(公告)日：2007-02-22
申请号：US11474761
申请日：2006-06-26
申请人： Dennis Bozung , Thomas Sundberg , Kelly Osborne
发明人： Dennis Bozung , Thomas Sundberg , Kelly Osborne
IPC分类号： B62H7/00
摘要： The present invention relates to a motorcycle anti-tipover device that has telescoping support arms that extend to the ground. The support arms are automatically extending when the motorcycle is stationary or moving at low speeds to prevent the motorcycle from tipping over. The telescoping support arms may also serve as a traditional kickstand, or may be used to lift the motorcycle during servicing. Alternatively, an airbag may be deployed underneath the motorcycle to prevent the motorcycle from tipping over.
摘要翻译： 本发明涉及一种具有向地面延伸的伸缩支撑臂的摩托车防倾翻装置。 当摩托车静止或以低速运动时，支撑臂自动延伸，以防止摩托车倾倒。 伸缩式支撑臂还可用作传统的支架，或者可用于在维修期间提升摩托车。 或者，气囊可以部署在摩托车下方，以防止摩托车倾倒。
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