公开(公告)号：US20140199693A1

公开(公告)日：2014-07-17

申请号：US14006089

申请日：2012-01-16

申请人： Thomas Wurdinger ,  Rolf Jonas Nilsson

发明人： Thomas Wurdinger ,  Rolf Jonas Nilsson

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6834 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

摘要翻译： 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：US10174365B2

公开(公告)日：2019-01-08

申请号：US14006089

申请日：2012-01-16

申请人： Thomas Wurdinger ,  Rolf Jonas Nilsson

发明人： Thomas Wurdinger ,  Rolf Jonas Nilsson

IPC分类号： C12Q1/68 ,  C12Q1/6834 ,  C12Q1/6886

摘要： The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.