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    Preparation of 4-substituted imidazoles from N-formyl-.alpha.-aminonitrile
    2.
    发明授权
    Preparation of 4-substituted imidazoles from N-formyl-.alpha.-aminonitrile 失效
    从N-甲酰基-α-氨基腈制备4-取代的咪唑

    公开(公告)号：US5359082A

    公开(公告)日：1994-10-25

    申请号：US36032

    申请日：1993-03-23

    申请人： Ulrich Koehler ,  Thomas-Michael Kahl ,  Horst Neuhauser ,  Hardo Siegel ,  Michael Kroener

    发明人： Ulrich Koehler ,  Thomas-Michael Kahl ,  Horst Neuhauser ,  Hardo Siegel ,  Michael Kroener

    IPC分类号： C07D233/54 ,  C07D233/58 ,  C07D521/00 ,  C07D233/56

    CPC分类号： C07D233/54 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D521/00

    摘要： A process for the preparation of 4-substituted imidazoles of the general formula ##STR1## in which R denotes C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.20 cycloalkyl, aryl, and C.sub.7 -C.sub.20 aralkyl,whereina) N-formyl-.alpha.-aminonitriles of the general formula I ##STR2## in which R has the meanings stated above and A stands for carbonyl, are reacted, at a temperature ranging from 20.degree. to 200.degree. C. and a pressure ranging from 20 to 500 bar, with hydrogen in the presence of hydrogenation catalysts andb) the resulting N-formyl-1,2-diamines of the general formula ##STR3## in which R and A have the meanings stated above and n stands for 0 or 1, are reacted over a cyclization/dehydrogenation catalyst at a temperature ranging from 200.degree. to 600.degree. C. and a pressure ranging from 0.001 to 5 bar.

    摘要翻译： 制备通式为（I）的4-取代咪唑的方法，其中R表示C 1 -C 20烷基，C 3 -C 20环烷基，芳基和C 7 -C 20芳烷基，其中a）N-甲酰基-α 其中R具有上述含义并且A代表羰基的通式I （II）的氨基腈在20℃至200℃的温度和20至500℃的压力下反应 在氢化催化剂的存在下用氢气b）所得的通式（III）的N-甲酰基-1,2-二胺其中R和A具有上述含义，n代表0或 1在环化/脱氢催化剂上在200至600℃的温度和0.001至5巴的压力下反应。