公开(公告)号：US07087247B2

公开(公告)日：2006-08-08

申请号：US10416472

申请日：2001-11-08

Applicant: Youxin Li ,  Detlef Mohr ,  Tim Seiffert

Inventor： Youxin Li ,  Detlef Mohr ,  Tim Seiffert

IPC: A61K9/50 ,  C08G63/08

CPC classification number: C08G63/08 ,  A61K9/1647 ,  C08G63/823

Abstract: The invention relates to novel absorbable polyesters, produced by ring-opening polymerisation of hydroxycarboxylic acids in the presence of a polyol containing an electrolyte, in an extruder. In particular, the invention relates to novel polylactide glycolide polyesters which are essentially free of dextran sulphate and which are produced by ring-opening polymerisation of lactide and glycolide in the presence of dextran sulphate in the extruder; to the production of the same and to their use in depot medicaments.

Abstract translation: 本发明涉及通过在挤出机中在含有电解质的多元醇存在下，通过羟基羧酸的开环聚合制备的新型可吸收聚酯。 特别地，本发明涉及基本上不含葡聚糖硫酸盐的新型聚丙交酯乙交酯聚酯，其通过在挤出机中在硫酸葡聚糖存在下由丙交酯和乙交酯的开环聚合制备; 生产和使用药剂。