公开(公告)号：US20240327782A1

公开(公告)日：2024-10-03

申请号：US18506930

申请日：2023-11-10

Applicant: The Regents of the University of California

Inventor： Tejal A. Desai ,  Crystal Nyitray ,  Ryan Chang

IPC: C12N5/00 ,  A61K9/00 ,  A61K47/34 ,  C08G63/08 ,  C12N5/071

CPC classification number: C12N5/0012 ,  A61K9/0024 ,  A61K47/34 ,  C08G63/08 ,  C12N5/0676

Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.

公开(公告)号：US12104011B2

公开(公告)日：2024-10-01

申请号：US17631057

申请日：2020-09-16

Applicant: LG CHEM, LTD.

Inventor： Banseok Choi ,  Jung Yun Choi ,  Chul Woong Kim ,  Sungwoon Heo ,  Eungwon Kim ,  Donggyun Kang

IPC: C08G63/08 ,  B29B7/38 ,  B29K67/00 ,  B29K96/04 ,  B29K105/00 ,  B29K105/06 ,  C08J3/20

CPC classification number: C08G63/08 ,  C08J3/203 ,  B29B7/38 ,  B29K2067/04 ,  B29K2096/04 ,  B29K2105/0085 ,  B29K2105/06 ,  C08J2367/04

Abstract: Provided is a biopolymer composition, a preparation method for the same, and a bioplastic using the same, the biopolymer composition comprising at least 83.5 weight % of a copolymer resin of lactic acid (LA) and 3-hydroxypropionate (3HP), an antioxidant, and a lubricant, and the composition having an elongation percentage of at least 90% but not greater than 500%.

公开(公告)号：US20240309149A1

公开(公告)日：2024-09-19

申请号：US18577985

申请日：2022-07-09

Applicant: CORNELL UNIVERSITY

Inventor： Geoffrey W. Coates ,  Anne M. LaPointe ,  Zhiyao Zhou

IPC: C08G63/08 ,  C07C51/09 ,  C08G63/82

CPC classification number: C08G63/08 ,  C07C51/09 ,  C08G63/823 ,  C08G2230/00

Abstract: Poly(dialkyl beta-lactone) (PDABL) compositions, methods of making same, and uses thereof. In various examples, the PDABL compositions are homopolymers or copolymers. The PDABL compositions comprise a plurality of dialkyl P-lactone (DABL) repeat units. The (PDABL) compositions can be formed by ring-opening polymerization of dialkyl-P-lactone(s). PDABL composition(s) can be used to form various articles of manufacture, such as, for example, packaging articles, single-use articles, sports articles, bio-medical articles, agricultural articles, automotive articles, electronic articles, and the like. In various examples, the PDABL composition or an article of manufacture is biodegradable.

公开(公告)号：US12084541B2

公开(公告)日：2024-09-10

申请号：US17598355

申请日：2020-03-30

Applicant: TOYO SEIKAN GROUP HOLDINGS, LTD.

Inventor： Tsutaki Katayama ,  Seishi Yoshikawa ,  Koki Shibata

IPC: C08G63/08 ,  C08K3/105 ,  C08K3/26

CPC classification number: C08G63/08 ,  C08K3/105 ,  C08K3/26

Abstract: A polylactic acid solid composition includes: a polylactic acid having a weight average molecular weight of not more than 40,000, which is measured in terms of polystyrene standard by GPC; and a basic compound of an alkali metal or an alkaline earth metal, which is a residue of a molecular weight reduction accelerator. The basic compound is contained in an amount in a range of 0.5 to 20 mass %.

公开(公告)号：US12070533B2

公开(公告)日：2024-08-27

申请号：US16642730

申请日：2018-08-30

Applicant: Tam Christine Thompson-Steckel

Inventor： David Russell Bow ,  Calum Bruce Macleod ,  Jeffrey Jump

IPC: A61F2/88 ,  A61F2/90 ,  A61L31/02 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  B33Y80/00 ,  C08G63/08 ,  C09D5/00 ,  C09D167/04 ,  C22C23/00 ,  A61F2/82

CPC classification number: A61L31/022 ,  A61F2/88 ,  A61F2/90 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  B33Y80/00 ,  C08G63/08 ,  C09D5/00 ,  C09D167/04 ,  C22C23/00 ,  A61F2002/825 ,  A61F2210/0004 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2250/0067

Abstract: There is described a bioresorbable metal alloy which is particularly suitable for the formation of bioresorbable medical devices, for example stents. The metal alloy essentially comprises 3.2 to 4.8% by weight lithium, 0.5 to 2.0% by weight yttrium; and the balance being magnesium, in addition to any trace elements. The metal alloy can be drawn into a wire which can be shaped into a stent scaffold. The stent can be produced using one or more stent scaffolds together with one or more bioresorbable polymer connectors, for example formed from PLGA.

公开(公告)号：US20240277854A1

公开(公告)日：2024-08-22

申请号：US18428147

申请日：2024-01-31

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Tim R. Blake ,  Paul Wender ,  Robert Waymouth ,  Ronald Levy ,  Ole Haabeth ,  Rebecca Mcclellan ,  Adrienne Sallets

IPC: A61K47/59 ,  A61K9/00 ,  A61K47/54 ,  A61K48/00 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/02

CPC classification number: A61K47/593 ,  A61K9/007 ,  A61K47/549 ,  A61K48/0041 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/028 ,  C08G73/0293

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo.

公开(公告)号：US12012681B2

公开(公告)日：2024-06-18

申请号：US17507790

申请日：2021-10-21

Applicant: CHINA YUNHONG HOLDINGS CO., LTD. ,  Yunhong Environmental Technology Co., Ltd. ,  Guozhong Xinghe Biomedical Technology Co., Ltd.

Inventor： Jingren He ,  Yubao Li ,  Dong Wu ,  Shuxin Ye ,  Sijia Jiang ,  Rui Zhang

IPC: D04H1/56 ,  B29B9/12 ,  C08G63/08 ,  C08G63/78 ,  C08G63/90 ,  C08G63/91 ,  D01D5/088

CPC classification number: D04H1/56 ,  B29B9/12 ,  C08G63/08 ,  C08G63/785 ,  C08G63/90 ,  C08G63/912 ,  D01D5/088 ,  D10B2331/041 ,  D10B2401/12

Abstract: Disclosed is a method for preparing a fully-degradable non-woven fabric by spun-bonding, including: (S1) preparation of a poly(caprolactone-co-lactide acid) (P(CL-co-LA)); (S2) preparation of a copolymerized-modified poly(lactide acid) (PLA); and (S3) preparation of a full-degradable non-woven fabric using a spun-bond method. In this disclosure, the PLA is modified in gradient several times to prepare the full-degradable non-woven fabric in combination with an optimized spun-bonding method.

公开(公告)号：US20240182633A1

公开(公告)日：2024-06-06

申请号：US18548777

申请日：2022-03-03

Applicant: Regents of the University of Minnesota

Inventor： Ian A. Tonks ,  Rachel Maria Rapagnani

IPC: C08G63/08 ,  C07D309/30 ,  C08G63/82 ,  C08G63/87 ,  C08G63/91

CPC classification number: C08G63/08 ,  C07D309/30 ,  C08G63/823 ,  C08G63/87 ,  C08G63/912

Abstract: Provided herein are methods of ring-opening polymerization of lactones to yield bioderived polyesters with varying backbone structures.

公开(公告)号：US20240132657A1

公开(公告)日：2024-04-25

申请号：US18276797

申请日：2022-09-20

Applicant: LG Chem, Ltd.

Inventor： Do Yeon Kim ,  Ho Yeon Son ,  Yang Gu Kang ,  Shin Hee Jun ,  Ha Na Lee ,  Jeong Hyun Lee

IPC: C08G18/42 ,  C08G18/12 ,  C08G63/08 ,  C08G63/82 ,  C08G63/85 ,  C08K3/22 ,  C08K5/11 ,  C08L75/06 ,  H01M10/653

CPC classification number: C08G18/4277 ,  C08G18/12 ,  C08G18/4202 ,  C08G63/08 ,  C08G63/823 ,  C08G63/85 ,  C08K3/22 ,  C08K5/11 ,  C08L75/06 ,  H01M10/653 ,  C08K2003/2227 ,  C08K2201/001 ,  C08K2201/003 ,  C08K2201/014 ,  C08L2201/02

Abstract: A curable composition or a thermal interface material exhibiting low adhesion force to a predetermined adherend while having a low density as well as exhibiting a high thermal conductivity is provided. It also has excellent flame retardant properties, and exhibits ejection properties and thixotropy suitable for processes in a state where halogen flame retardants or phosphorus-based flame retardants are not used, or the use ratio thereof is minimized.

公开(公告)号：US11965090B2

公开(公告)日：2024-04-23

申请号：US16981676

申请日：2019-03-20

Applicant: ERCROS, S.A.

Inventor： Martí Hortós Lobera ,  Jordi Bou Serra ,  Sebastián Espino Sosa

IPC: C08L67/04 ,  B29C45/00 ,  C08K5/053 ,  C08K7/00 ,  B29K67/00 ,  C08G63/08

CPC classification number: C08L67/04 ,  B29C45/0001 ,  C08K5/053 ,  C08K7/00 ,  B29K2067/046 ,  C08G63/08

Abstract: The present invention relates to a composition comprising a polymer which comprises poly(lactic acid) and an additive which comprises dipentaerythritol, wherein the weight percentage of the polymer is from 80 to 99.5%, and the weight percentage of the additive is from 0.5 to 20%. It also relates to the use of dipentaerythritol as a nucleating agent for polymers comprising poly(lactic acid); to a process for the preparation of moulded article from the composition comprising the polymer which comprises poly(lactic acid) and an additive which comprises dipentaerythritol; and to an injection moulded article made therefrom.