公开(公告)号：US07928231B2

公开(公告)日：2011-04-19

申请号：US12411818

申请日：2009-03-26

Applicant: John Gerard Jurcak ,  Matthieu Barrague ,  Timothy Alan Gillespy ,  Michael Louis Edwards ,  Kwon Yon Musick ,  Philip Marvin Weintraub ,  Yan Du ,  Ramalinga M. Dharanipragada ,  Ashfaq Ahmad Parkar

Inventor： John Gerard Jurcak ,  Matthieu Barrague ,  Timothy Alan Gillespy ,  Michael Louis Edwards ,  Kwon Yon Musick ,  Philip Marvin Weintraub ,  Yan Du ,  Ramalinga M. Dharanipragada ,  Ashfaq Ahmad Parkar

IPC: C07D403/00 ,  C07D231/54

CPC classification number: C07D495/04

Abstract: Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

Abstract translation: 式I的噻吩并吡唑类，其制备方法，包含这些化合物的药物组合物及其在治疗能够通过抑制蛋白激酶（特别是白细胞介素-2诱导型酪氨酸激酶（ITK））调节的疾病状态的药物用途。

公开(公告)号：US20090036469A1

公开(公告)日：2009-02-05

申请号：US12246918

申请日：2008-10-07

Applicant: David STEFANY ,  Keith John HARRIS ,  Timothy Alan GILLESPY ,  Charles J. GARDNER ,  Joacy C. AGUIAR

Inventor： David STEFANY ,  Keith John HARRIS ,  Timothy Alan GILLESPY ,  Charles J. GARDNER ,  Joacy C. AGUIAR

IPC: C07D239/47 ,  A61K31/506 ,  A61K31/505 ,  C07D401/04 ,  C07D409/04 ,  A61K31/495 ,  A61P37/08 ,  A61P17/00 ,  A61P11/00

CPC classification number: C07D403/04 ,  C07D239/47 ,  C07D409/04

Abstract: The present invention is directed to a compound of formula (I), wherein R1 and R2 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds of the invention in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder by administering to said patient a pharmaceutically effective amount of a compound of the invention.

Abstract translation: 本发明涉及式（I）化合物，其中R 1和R 2如本文所定义，药物组合物包含药学上有效量的一种或多种本发明化合物与药学上可接受的载体的混合物，以及方法 通过向所述患者施用药学有效量的本发明化合物来治疗患有PGD2介导的病症的患者。

公开(公告)号：US20100056514A1

公开(公告)日：2010-03-04

申请号：US12411818

申请日：2009-03-26

Applicant: John Gerard JURCAK ,  Matthieu BARRAGUE ,  Timothy Alan GILLESPY ,  Michael Louis EDWARDS ,  Kwon Yon MUSICK ,  Philip Marvin WEINTRAUB ,  Yan DU ,  Ramalinga M. DHARANIPRAGADA ,  Ashfaq Ahmad PARKAR

Inventor： John Gerard JURCAK ,  Matthieu BARRAGUE ,  Timothy Alan GILLESPY ,  Michael Louis EDWARDS ,  Kwon Yon MUSICK ,  Philip Marvin WEINTRAUB ,  Yan DU ,  Ramalinga M. DHARANIPRAGADA ,  Ashfaq Ahmad PARKAR

IPC: A61K31/4162 ,  C07D495/04 ,  C07D413/14 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61P11/06

CPC classification number: C07D495/04

Abstract: Thienopyrazoles, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

Abstract translation: 噻吩并吡唑类，它们的制剂，包含这些化合物的药物组合物及其药物用途，用于治疗能够通过抑制蛋白激酶（特别是白细胞介素-2诱导型酪氨酸激酶（ITK））调节的疾病状态。

公开(公告)号：US07518000B2

公开(公告)日：2009-04-14

申请号：US11368566

申请日：2006-03-06

Applicant: John Gerald Jurcak ,  Matthieu Barrague ,  Timothy Alan Gillespy ,  Michael Louis Edwards ,  Kwon Yon Musick ,  Phillip Marvin Weintraub ,  Yan Du ,  Ramalinga M. Dharanipragada ,  Ashfaq Ahmed Parkar

Inventor： John Gerald Jurcak ,  Matthieu Barrague ,  Timothy Alan Gillespy ,  Michael Louis Edwards ,  Kwon Yon Musick ,  Phillip Marvin Weintraub ,  Yan Du ,  Ramalinga M. Dharanipragada ,  Ashfaq Ahmed Parkar

IPC: C07D495/02 ,  C07D231/54

CPC classification number: C07D495/04

Abstract: Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

Abstract translation: 式I的噻吩并吡唑类，其制备方法，包含这些化合物的药物组合物及其在治疗能够通过抑制蛋白激酶（特别是白细胞介素-2诱导型酪氨酸激酶（ITK））调节的疾病状态的药物用途。