公开(公告)号：US20080064896A1

公开(公告)日：2008-03-13

申请号：US11893783

申请日：2007-08-17

Applicant: Ashok Luhadiya ,  Timothy Dake ,  Glenn Hudepohl ,  Donald Compton

Inventor： Ashok Luhadiya ,  Timothy Dake ,  Glenn Hudepohl ,  Donald Compton

IPC: C07C69/66

CPC classification number: A61K33/06 ,  A61K9/1688 ,  A61K31/19 ,  A61K31/194 ,  C07C59/245 ,  C07C59/265

Abstract: A process for producing a calcium citrate malate composition by the steps of: combining a calcium source, a citrate source, a malate source and water to form a calcium citrate malate mixture. The mixture is reacted until reaching a peak temperature of from about 45° C. to about 70° C., and then cooled at a rate of from about 1° C./minute to about 4° C./minute to reach a final temperature of less than about 40° C. A calcium citrate malate precipitate is formed and then dried to obtain the calcium citrate malate composition.

Abstract translation: 一种通过以下步骤生产柠檬酸柠檬酸苹果酸组合物的方法：将钙源，柠檬酸盐源，苹果酸盐和水混合以形成柠檬酸柠檬酸苹果酸盐混合物。 使混合物反应直到达到约45℃至约70℃的峰值温度，然后以约1℃/分钟至约4℃/分钟的速率冷却以达到最终 温度低于约40℃。形成柠檬酸苹果酸柠檬酸盐沉淀，然后干燥，得到柠檬酸苹果酸钙组合物。

公开(公告)号：US20080045597A1

公开(公告)日：2008-02-21

申请号：US11893708

申请日：2007-08-17

Applicant: Ashok Luhadiya ,  Timothy Dake ,  Glenn Hudepohl ,  Donald Compton

Inventor： Ashok Luhadiya ,  Timothy Dake ,  Glenn Hudepohl ,  Donald Compton

IPC: A61K31/194 ,  A23L1/304 ,  A61P19/00 ,  C07C59/265

CPC classification number: A61K33/06 ,  A61K9/145 ,  A61K9/1688 ,  A61K31/19 ,  C07C59/245 ,  C07C59/265

Abstract: Compositions containing calcium citrate malate wherein the calcium citrate malate exhibits one or more of: a pore area of at least about 30 m2/g; a dissolution rate of at least about 95% by weight of the calcium citrate malate in less than about 120 seconds.

Abstract translation: 含有柠檬酸苹果酸钙的组合物，其中柠檬酸苹果酸钙显示出以下一种或多种：孔面积至少约30m 2 / g; 至少约95重量％的柠檬酸苹果酸钙的溶解速率在小于约120秒内。