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公开(公告)号：US08711474B2
公开(公告)日：2014-04-29
申请号：US12825067
申请日：2010-06-28
CPC分类号： G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
摘要： A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
摘要翻译： 公开了一种使用模块显微镜的系统，装置和方法。 连接各个显微镜模块的外壳提供了模块化显微镜的结构框架。 此外，模块化显微镜可以包括专门的软件，可以使用存储在一个或多个显微镜模块上的安全密钥或标识符来控制其分布和使用。 安全密钥和标识符可以基于与多个模块之一的物理，电或光学特性相关联的校准数据。 所公开的照明模块为亮场和暗场照明提供了可选择的波长和输出照明的可控电平。
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公开(公告)号：US20130102481A1
公开(公告)日：2013-04-25
申请号：US13449061
申请日：2012-04-17
申请人： Tom McCollum
发明人： Tom McCollum
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , C40B60/12 , G01N21/253 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6421 , G01N2201/0627
摘要： In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certain embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession.
摘要翻译： 在用于检测和区分多个样本中的多个样本中的多个目标的扫描系统中，一个或多个多频带荧光检测通道每个包含单个多频带发射滤波器和单个检测器，代替扫描头中的多个检测组件 现有技术 在某些实施例中，也使用单个多发射器光源，以连续的各种不同波长的激发光照射每个样品。
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公开(公告)号：US20100328766A1
公开(公告)日：2010-12-30
申请号：US12825067
申请日：2010-06-28
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
摘要： A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
摘要翻译： 公开了一种使用模块显微镜的系统，装置和方法。 连接各个显微镜模块的外壳提供了模块化显微镜的结构框架。 此外，模块化显微镜可以包括专门的软件，可以使用存储在一个或多个显微镜模块上的安全密钥或标识符来控制其分布和使用。 安全密钥和标识符可以基于与多个模块之一的物理，电或光学特性相关联的校准数据。 所公开的照明模块为亮场和暗场照明提供了可选择的波长和输出照明的可控电平。
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公开(公告)号：USH801H
公开(公告)日：1990-07-03
申请号：US336456
申请日：1989-03-17
申请人： Walter Koechner , Deborah R. Van Wyck , Gary P. Stevenson , William Krug , Tom McCollum , Garry B. Spector
发明人： Walter Koechner , Deborah R. Van Wyck , Gary P. Stevenson , William Krug , Tom McCollum , Garry B. Spector
IPC分类号： G01T5/08
CPC分类号： G01T1/201
摘要： A nuclear radiation detection system for remote monitoring of movement of nuclear material over a road or highway. Nuclear fiber sensors, which may be several meters long, are covertly positioned in at least two monitoring points, such as buried shallowly under the roadway or hung from a tunnel wall, along the path which a nuclear source may be clandestinely moved. These fiber sensors are individually connected, by an epoxy glue, to individual transmitting optical fibers. Movement of a nuclear radiation source in close proximity to the fiber sensors at the two or more monitoring points produces an optical signal which exceeds a preestablished threshold. These optical signals travel through the transmitting optical fibers, which may be about 1 kilometers long, to a electronic system comprised of a microprocessor controlled signal detecting, signal processing and even data storage means. The optical fibers and electronic system are also selectively hidden from view for security reasons. Any movement of a nuclear source is detected by strength and duration radiation signal data which is stored in the microprocessor memory. This data may be removed from the processor and read out by a data key means.
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公开(公告)号：US08570370B2
公开(公告)日：2013-10-29
申请号：US12869979
申请日：2010-08-27
申请人： Tom McCollum , Paul Patt , Frank Shen , Daniel Y. Chu , Don Flory , Mike Griffin , Xin Heng , Eli Hefner
发明人： Tom McCollum , Paul Patt , Frank Shen , Daniel Y. Chu , Don Flory , Mike Griffin , Xin Heng , Eli Hefner
IPC分类号： G06K9/00
CPC分类号： C12Q1/06 , G01N15/1434 , G02B21/0008 , G02B21/34
摘要： Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
摘要翻译： 将液体悬浮液中的生物细胞计数在自动细胞计数器中，其将悬浮液的图像聚焦在数字成像传感器上，该数字成像传感器包含至少4,000,000个像素，每个具有2×2μm或更小的面积，并且图像的视场 至少3 mm2。 该传感器使得计数器能够将光学部件压缩成高度小于20cm的光路，当垂直布置时，整个光路的方向没有变化，并且整个仪器的占地面积小于300cm 2。 光源的激活，传感器图像的自动聚焦和数字单元计数都是通过将样品架简单插入到仪器中来启动的。 将悬浮液置于样品室中，其形状为成形以确保细胞计数器中载玻片的正确取向。
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公开(公告)号：US5298756A
公开(公告)日：1994-03-29
申请号：US961661
申请日：1992-10-16
申请人： Tom McCollum , Garry B. Spector
发明人： Tom McCollum , Garry B. Spector
IPC分类号： G01T3/06
CPC分类号： G01T3/06
摘要： A flat response position sensitive neutron detector capable of providing neutron spectroscopic data utilizing scintillator fiber optic filaments embedded in a neutron moderating housing having an open end through which neutrons enter to be detected.
摘要翻译： 平坦的响应位置敏感的中子探测器，能够利用嵌入中子调节壳体中的闪烁体光纤提供中子光谱数据，该中子调节壳体具有中子进入以被检测的开口端。
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公开(公告)号：US09329127B2
公开(公告)日：2016-05-03
申请号：US13449061
申请日：2012-04-17
申请人： Tom McCollum
发明人： Tom McCollum
CPC分类号： G01N21/6428 , C40B60/12 , G01N21/253 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6421 , G01N2201/0627
摘要： In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certain embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession.
摘要翻译： 在用于检测和区分多个样本中的多个样本中的多个目标的扫描系统中，一个或多个多频带荧光检测通道每个包含单个多频带发射滤波器和单个检测器，代替扫描头中的多个检测组件 现有技术 在某些实施例中，也使用单个多发射器光源，以连续的各种不同波长的激发光照射每个样品。
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8.发明授权
公开(公告)号：US4931646A
公开(公告)日：1990-06-05
申请号：US336455
申请日：1989-03-17
CPC分类号： G01T1/201 , G01T1/2008
摘要： A multichannel coincidence nuclear detector system for spectral charactertion of nuclear radiation sources at a remote location. The system is designed to detect and classify the radiation source in unfriendly territory and to provide a radio link back to a friendly receiver user station. The sensing elements are comprised of a plurality of plastic scintillator fiber sensors which may be several meters long and with each fiber having a different spectral sensitivity to gamma and neutron sources. Each of the scintillator fibers is connected to a transmitting optical fiber which may be 1 kilometer or more in length. The plurality of optical fibers transmit the optical signal generated by the radiation from a nuclear source impinging on the scintillator fibers to an electronic system. The electronic system is a sealed self contained battery operated device which is comprised of a photomuliplier detector and microprocessor based signal processing and data storage. The microprocessor compares the input signals from each scintillator fiber and determines the energy source. The data is stored in the microprocessor and may be interrogated by a radio frequency link to at a receiver station many kilometers away. The fiber sensors, optical fibers, and the electronics system including a transmitting antenna are all covertly positioned to prevent being observed by an unauthorized person.
摘要翻译： 用于远程位置的核辐射源的光谱表征的多通道重合核探测器系统。 该系统旨在检测和分类不友好地区的辐射源，并将无线电链路提供回友好的接收机用户站。 感测元件由多个塑料闪烁体光纤传感器组成，其可以是几米长，并且每个光纤对伽马和中子源具有不同的光谱灵敏度。 每个闪烁体光纤连接到长度可能为1公里或更长的发送光纤。 多个光纤将来自入射到闪烁体光纤上的核辐射的辐射产生的光信号传输到电子系统。 电子系统是一种密封的自包含电池供电装置，由光电检测器和基于微处理器的信号处理和数据存储组成。 微处理器比较来自每个闪烁体光纤的输入信号并确定能量源。 数据存储在微处理器中，并且可以通过射频链路询问到距离许多公里的接收站。 包括发射天线的光纤传感器，光纤和电子系统都被隐蔽定位以防止被未经授权的人员观察到。
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公开(公告)号：US20110211058A1
公开(公告)日：2011-09-01
申请号：US12869979
申请日：2010-08-27
申请人： Tom McCollum , Paul Patt , Frank Shen , Daniel Y. Chu , Don Flory , Mike Griffin , Xin Heng , Eli Hefner
发明人： Tom McCollum , Paul Patt , Frank Shen , Daniel Y. Chu , Don Flory , Mike Griffin , Xin Heng , Eli Hefner
CPC分类号： C12Q1/06 , G01N15/1434 , G02B21/0008 , G02B21/34
摘要： Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
摘要翻译： 液体悬浮液中的生物细胞在自动细胞计数器中计数，其将悬浮液的图像聚焦在包含至少4,000,000个像素的数字成像传感器上，每个具有2×2μm或更小的面积，并且图像的视场 至少3 mm2。 该传感器使得计数器能够将光学部件压缩成高度小于20cm的光路，当垂直布置时，整个光路的方向没有变化，并且整个仪器的占地面积小于300cm 2。 光源的激活，传感器图像的自动聚焦和数字单元计数都是通过将样品架简单插入到仪器中来启动的。 将悬浮液置于样品室中，其形状为成形以确保细胞计数器中载玻片的正确取向。
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