公开(公告)号：US4521406A

公开(公告)日：1985-06-04

申请号：US265563

申请日：1981-05-20

申请人： Yasuo Kawamura ,  Tadashi Nishiyama ,  Tomiyoshi Itoh ,  Takuo Sakai

发明人： Yasuo Kawamura ,  Tadashi Nishiyama ,  Tomiyoshi Itoh ,  Takuo Sakai

IPC分类号： C07D239/47 ,  A61K31/505 ,  A61K38/43 ,  A61K38/46 ,  A61P35/00 ,  A61K37/48 ,  A61K31/70

CPC分类号： C12Y305/04001 ,  A61K31/513 ,  A61K38/50

摘要： An antitumor agent comprising a combination of 5-fluorocytosine and cytosinedeaminase has been developed. As to the practical administration procedure of the agent, it is preferable to carry out in such a manner that 5-fluorocytosine is first administered in any portion of the body, and cytosinedeaminase is then administered into the topically suffered portion. The administered 5-fluorocytosine is transferred into the suffered portion, and the 5-fluorocytosine is affected with the action of cytosinedeaminase to convert the former compound into 5-fluorouracil, resulting in that the necrosis of the tumor tissue is caused.

摘要翻译： 已经开发了包含5-氟胞嘧啶和胞嘧啶胞嘧啶的组合的抗肿瘤剂。 对于试剂的实际给药程序，优选以首先在体内任何部位施用5-氟胞嘧啶的方式进行，然后将细胞内氨基甙酶施用于局部受累部位。 将所施用的5-氟胞嘧啶转移到受损部分中，5-氟胞嘧啶受细胞胞嘧啶酶的作用影响，将前者化合物转化为5-氟尿嘧啶，导致肿瘤组织的坏死。