公开(公告)号：US06329382B1

公开(公告)日：2001-12-11

申请号：US09355935

申请日：1999-08-13

申请人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Masashi Tamai ,  Naoki Hiyama ,  Yukio Kawazu ,  Tomoaki Yahiro ,  Mayumi Sugio

发明人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Masashi Tamai ,  Naoki Hiyama ,  Yukio Kawazu ,  Tomoaki Yahiro ,  Mayumi Sugio

IPC分类号： C07D48714

CPC分类号： C07D487/14 ,  A61K31/519

摘要： The invention relates to a therapeutic and preventive medicament for respiratory diseases, comprising, as an active ingredient, a compound represented by the general formula (1): wherein R1 represents a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms; and R2 represents a hydrogen or halogen atom, a substituted alkyl group, an amino group which may be substituted, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, or an alkylcarbamoyl group, or a salt thereof. This compound has excellent tracheobronchodilative effect and inhibitory effect on airway constriction.

摘要翻译： 本发明涉及用于呼吸系统疾病的治疗和预防药物，其包含作为活性成分的由通式（1）表示的化合物：其中R 1表示具有1至10个碳原子的直链，支链或环状烷基; R 2表示氢或卤原子，取代烷基，可被取代的氨基，羧基，烷氧基羰基，氨基甲酰基或烷基氨基甲酰基或其盐。 该化合物对气道收缩具有优异的气管支气管扩张作用和抑制作用。

公开(公告)号：US5942515A

公开(公告)日：1999-08-24

申请号：US17223

申请日：1998-02-02

申请人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Yukio Kawazu ,  Kenichi Kishii ,  Norio Funayama ,  Mariko Harada ,  Kyoko Taneda ,  Naoki Hiyama ,  Tomoaki Yahiro ,  Mayumi Sugio ,  Masashi Tamai

发明人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Yukio Kawazu ,  Kenichi Kishii ,  Norio Funayama ,  Mariko Harada ,  Kyoko Taneda ,  Naoki Hiyama ,  Tomoaki Yahiro ,  Mayumi Sugio ,  Masashi Tamai

IPC分类号： A61K31/505 ,  A61P11/00 ,  C07D487/04 ,  C07D487/14 ,  A01N43/54 ,  C07D239/00

CPC分类号： C07D487/04 ,  C07D487/14

摘要： The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

公开(公告)号：US6057330A

公开(公告)日：2000-05-02

申请号：US236093

申请日：1999-01-25

申请人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Yukio Kawazu ,  Kenichi Kishii ,  Norio Funayama ,  Mariko Harada ,  Kyoko Taneda ,  Naoki Hiyama ,  Tomoaki Yahiro ,  Mayumi Sugio ,  Masashi Tamai

发明人： Takayuki Namiki ,  Masayuki Yuasa ,  Takako Takakuwa ,  Satoshi Ichinomiya ,  Yukio Kawazu ,  Kenichi Kishii ,  Norio Funayama ,  Mariko Harada ,  Kyoko Taneda ,  Naoki Hiyama ,  Tomoaki Yahiro ,  Mayumi Sugio ,  Masashi Tamai

IPC分类号： A61K31/505 ,  A61P11/00 ,  C07D487/04 ,  C07D487/14 ,  A01N43/54 ,  C07D239/00

CPC分类号： C07D487/04 ,  C07D487/14

摘要： The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

摘要翻译： 本发明涉及由以下通式（1）表示的化合物：其中R1表示烷基，R2表示氨基，烷基等，R3表示硝基，氨基，杂环基，烷基磺酰基氨基或 类似物或其盐，包含这种化合物的药物，该化合物的制备方法和可用于其制备的中间体。 化合物（1）可用于预防和治疗呼吸系统疾病。