公开(公告)号：US06429316B1

公开(公告)日：2002-08-06

申请号：US09447237

申请日：1999-11-23

申请人： Kazunari Takahashi ,  Yoko Seto ,  Masaru Utsunomiya ,  Souichi Orita ,  Kazutaka Maruyama ,  Tomonori Okubi

发明人： Kazunari Takahashi ,  Yoko Seto ,  Masaru Utsunomiya ,  Souichi Orita ,  Kazutaka Maruyama ,  Tomonori Okubi

IPC分类号： C07D20746

CPC分类号： C07D207/267

摘要： Disclosed is a process for preparing a pyrrolidone derivative, which comprises allowing at least one of &ggr;-butyrolactone, 4-hydroxybutyric acid, and a low-molecular polymer of 4-hydroxybutyric acid to react with an alkylamine, wherein (i) the content of a primary amine in said alkylamine is 85% by weight or lower, and (ii) the molar ratio of the total amount of the charged primary and secondary amines to the total amount of the charged &ggr;-butyrolactone, 4-hydroxybutyric acid, and low-molecular 4-hydroxybutyric acid polymers satisfies formula: 1.0≦(A1+A2/2.5)/(B1+B2+B3) wherein A1, A2, B1, B2, and B3 represent the molar amounts of a primary amine, a secondary amine, &ggr;-butyrolactone, 4-hydroxybutyric acid, and low-molecular 4-hydroxybutyric acid polymers, respectively.

摘要翻译： 公开了一种制备吡咯烷酮衍生物的方法，其包括使γ-丁内酯，4-羟基丁酸和4-羟基丁酸的低分子量聚合物中的至少一种与烷基胺反应，其中（i） 所述烷基胺中的伯胺为85重量％以下，（ii）带电荷的伯胺与仲胺的总量相对于带电量的γ-丁内酯，4-羟基丁酸的总量的摩尔比为低 分子式4-羟基丁酸聚合物满足式：其中A1，A2，B1，B2和B3代表伯胺，仲胺，γ-丁内酯，4-羟基丁酸和低分子量的4-羟基丁酸的摩尔量 酸聚合物。