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38 条记录 (耗时 0.019 秒)

    SALT FORMS OF S-(N, N-DIETHYLCARBAMOYL)GLUTATHIONE
    3.
    发明申请
    SALT FORMS OF S-(N, N-DIETHYLCARBAMOYL)GLUTATHIONE 有权

    公开(公告)号：US20220153780A1

    公开(公告)日：2022-05-19

    申请号：US17442258

    申请日：2020-03-26

    申请人： Tonix Pharma Holdings Limited

    发明人： Gregory M. Sullivan ,  Siobhan J. Fogarty

    IPC分类号： C07K5/02

    摘要： The invention relates in various aspects to a salt form S—(N, N-diethylcarbamoyl)glutathione, a method of producing the salt form, a pharmaceutical composition comprising said salt form. The invention also relates to a method of preventing or treating a glutamate-related disorder comprising administering to said subject a therapeutically effective amount of said salt form.

    METHOD FOR TREATING NEUROCOGNITIVE DYSFUNCTION
    7.
    发明申请
    METHOD FOR TREATING NEUROCOGNITIVE DYSFUNCTION 有权

    公开(公告)号：US20210177862A1

    公开(公告)日：2021-06-17

    申请号：US16937919

    申请日：2020-07-24

    申请人： Tonix Pharma Holdings Limited

    发明人： Gregory M. Sullivan

    IPC分类号： A61K31/554 ,  A61K31/56 ,  A61K31/573

    摘要： A method of treating corticosteroid-induced cognitive impairment comprises administering an effective amount of at least one compound of formula I, or pharmaceutically acceptable salts thereof, to a subject in need of such treatment Formula I is: wherein: A is a bridge selected from the following radicals: —(CH2)m—, —CH═CH—, —(CH2)p—O—, —(CH2)p—S—, —(CH2)p—SO2—, —(CH2)p—NR1— and —SO2—NR2—, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R1 is selected from the group consisting of hydrogen and C1-C5 alkyl; and R2 is C1-C5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and R′ are independently selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon.