公开(公告)号：US20060142222A1

公开(公告)日：2006-06-29

申请号：US10547710

申请日：2004-03-03

申请人： Makoto Ogino ,  Tomohiro Hirose ,  Kazumi Hayashi ,  Tomonobu Koizumi ,  Toshihide Yokoyama

发明人： Makoto Ogino ,  Tomohiro Hirose ,  Kazumi Hayashi ,  Tomonobu Koizumi ,  Toshihide Yokoyama

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04 ,  A61K38/54 ,  C12N9/99

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4712 ,  G01N2500/10

摘要： This discloses a novel human or rat polypeptide useful in improving and/or preventing organ fibrosis and a polynucleotide encoding the aforementioned polypeptide, an expression vector containing the aforementioned polynucleotide, and a cell transfected with the aforementioned expression vector. The aforementioned polynucleotide shows a remarkable decrease in the expression dose in the kidney of a chronic renal insufficiency model rat and in the bladder of a rat suffering from the induction of fibrotic conditions in the bladder, compared with a normal individual. Also, the production of extracellular matrix is suppressed by overexpression of the aforementioned polypeptide. Also disclosed are the promoter region of the aforementioned polypeptide, a method for screening a remedy for fibrotic conditions, and a process for producing a medicinal composition for improving fibrotic conditions which contains a substance obtained by the aforementioned screening method as the active ingredient.

摘要翻译： 这公开了可用于改善和/或预防器官纤维化的新型人或大鼠多肽和编码上述多肽的多核苷酸，含有上述多核苷酸的表达载体和用上述表达载体转染的细胞。 与正常个体相比，上述多核苷酸表现出慢性肾功能不全模型大鼠肾脏和膀胱中诱导纤维化病症的大鼠膀胱中的表达剂量显着降低。 此外，通过上述多肽的过表达来抑制细胞外基质的产生。 还公开了上述多肽的启动子区域，筛选纤维化病症的治疗方法，以及生产用于改善纤维化病症的药物组合物的方法，其含有通过上述筛选方法获得的物质作为活性成分。