公开(公告)号：US5580903A

公开(公告)日：1996-12-03

申请号：US370815

申请日：1995-01-10

申请人： Kazunori Mawatari ,  Katsumi Maezono ,  Hiromitsu Arai ,  Toshio Maki

发明人： Kazunori Mawatari ,  Katsumi Maezono ,  Hiromitsu Arai ,  Toshio Maki

IPC分类号： A61K31/195 ,  A61K31/198 ,  A61K38/00 ,  A61P1/16 ,  A61K31/205

CPC分类号： A61K31/195 ,  A61K31/198 ,  Y10S514/893 ,  Y10S514/894

摘要： A method of treating a patient in need of stimulation of hepatocyte mitosis which comprises administering to said patient an effective amount of alanine and/or glutamine.

摘要翻译： 一种治疗需要刺激肝细胞有丝分裂的患者的方法，其包括向所述患者施用有效量的丙氨酸和/或谷氨酰胺。

公开(公告)号：US4505144A

公开(公告)日：1985-03-19

申请号：US467505

申请日：1983-02-18

申请人： Kazuyoshi Sakuma ,  Tetsuo Nihei ,  Toshio Maki

发明人： Kazuyoshi Sakuma ,  Tetsuo Nihei ,  Toshio Maki

IPC分类号： B21D41/04 ,  B21J9/06 ,  B21K21/12 ,  B21D22/00

CPC分类号： B21D41/04 ,  B21J9/06 ,  B21K21/12

摘要： An apparatus for working both ends of a workpiece at a time. The workpiece, typically in the form of a bar or a tube, is successively shaped by pre-shaping die means, shaping die means and finish-shaping die means, each of which comprises a pair of dies for simultaneously working both ends of the workpiece to a predetermined configuration. The dies in each pair are movable toward and away from the both ends of the workpiece, respectively, in accordance with the operation of a pair of hydraulic devices. A pair of knockout rods respectively slidably received in cylinders of the hydraulic devices cooperate to support the workpiece while the latter is progressively shaped. One of the knockout rods is fixed to one of the dies while the other knockout rod is held afloat relative to the other die by a hydraulic device, so that the workpiece is allowed to stretch to a full available length only at one end thereof on the afloat knockout rod side.

摘要翻译： 一次工件两端的装置。 典型地为棒或管的形式的工件通过预成型模具装置，成型模具装置和精加工成型模具装置连续成型，每个模具包括一对模具，用于同时工作工件的两端 到预定的配置。 根据一对液压装置的操作，每对中的模具分别可移动和分离工件的两端。 分别可滑动地容纳在液压装置的气缸中的一对脱模杆配合以支撑工件，而后者是逐渐变形的。 其中一个脱模棒固定在其中一个模具上，而另一个脱模杆通过液压装置相对于另一个模具保持浮动，从而允许工件仅在其一端伸展至完全可用长度 漂浮的脱模杆侧。

公开(公告)号：US4167197A

公开(公告)日：1979-09-11

申请号：US757861

申请日：1977-01-10

申请人： Toshio Maki ,  Isao Oki ,  Kiyoshi Shirai

发明人： Toshio Maki ,  Isao Oki ,  Kiyoshi Shirai

IPC分类号： F15B13/02 ,  F15B13/08 ,  F16K11/07 ,  F16K11/10

CPC分类号： F15B13/08 ,  F15B13/02 ,  F16K11/0716 ,  Y10T137/5109 ,  Y10T137/5283 ,  Y10T137/87169

摘要： A directional change-over valve which has a valve body having connecting surfaces at both sides thereof, a spool slidably inserted into the valve body, a check valve replaceable depending upon utilities thereof, wherein the valve body has a plurality of valve chambers, the central valve chamber is communicated with the hole for mounting the check valve for removably mounting the check valve, passages are provided opening at the connecting surfaces of the valve body in the respective valve chambers, another passages are provided for connecting the interior of the check valve to the both side valve chambers to form parallel, tandem and series circuits. Thus, this invention simplifies the structure and circuits to provide a compact directional change-over valve device as a whole.

摘要翻译： 一种方向转换阀，其具有在其两侧具有连接表面的阀体，可滑动地插入阀体中的阀芯，根据其用途可更换的止回阀，其中阀体具有多个阀室，中心 阀室与用于安装止回阀的孔连通，用于可拆卸地安装止回阀，通道在相应的阀室中的阀体的连接表面处设置开口，另一通道用于将止回阀的内部连接到 两侧阀室形成并联，串联和串联回路。 因此，本发明简化了作为整体提供紧凑型方向转换阀装置的结构和电路。

公开(公告)号：US20080051438A1

公开(公告)日：2008-02-28

申请号：US11837727

申请日：2007-08-13

申请人： Shinobu Nagahama ,  Takeo Norimatsu ,  Toshio Maki ,  Masaharu Yasuda ,  Shinsuke Tanaka

发明人： Shinobu Nagahama ,  Takeo Norimatsu ,  Toshio Maki ,  Masaharu Yasuda ,  Shinsuke Tanaka

IPC分类号： A61K31/44 ,  A61P9/12

CPC分类号： A61K31/44 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides compositions that exert a superior hypotensive action while inhibiting an increase in heart rate. The present invention provides antihypertensives and preventive/therapeutic compositions useful in the treatment of cardiovascular diseases, which contain cilnidipine and at least one angiotensin II receptor blocker(s). The present invention also provides methods for treating cardiovascular diseases by administration of said compositions.

摘要翻译： 本发明提供了在抑制心率增加的同时发挥优异的降压作用的组合物。 本发明提供了可用于治疗心血管疾病的抗高血压药和预防/治疗组合物，其含有西尼地平和至少一种血管紧张素II受体阻断剂。 本发明还提供了通过施用所述组合物治疗心血管疾病的方法。

公开(公告)号：US5186082A

公开(公告)日：1993-02-16

申请号：US739460

申请日：1991-08-02

申请人： Masao Kuramitsu ,  Toshio Maki

发明人： Masao Kuramitsu ,  Toshio Maki

IPC分类号： B21K1/14 ,  B21J5/12 ,  B21K1/76

CPC分类号： F16D3/2237 ,  B21J5/12 ,  B21K1/762 ,  B21K1/765 ,  F16D2250/00

摘要： An ironing punch for ironing the socket of a ball-and-socket joint has a punch body with a plurality of circumferentially spaced ridges disposed on an outer circumferential surface thereof and extending from a distal end surface. The ironing punch also includes a plurality of ridge-shaped dies fitted respectively in recesses defined between the ridges on the punch body. Each of the ridges is ground by a single grinding wheel with the ridge-shaped dies removed from the punch body, and each of the ridge-shaped dies is also ground by a single grinding wheel. The punch body has relief grooves for preventing the grinding wheel from physical interference with junctions between the recesses and the distal end surface.

摘要翻译： 用于熨烫球窝接头的熨斗的熨烫冲头具有冲压体，该冲头本体具有设置在其外圆周表面上并从远端表面延伸的多个周向间隔开的脊。 熨烫冲头还包括分别装配在冲头主体上的脊之间的凹部中的多个脊形模具。 每个脊通过单个砂轮研磨，其中脊形模具从冲头主体移除，并且每个脊形模具也通过单个研磨轮研磨。 冲头体具有用于防止砂轮对凹部和远端表面之间的接合部的物理干扰的释放槽。

公开(公告)号：US4739644A

公开(公告)日：1988-04-26

申请号：US947737

申请日：1986-12-30

申请人： Toshio Maki ,  Masao Kuramitsu ,  Kaoru Yamanoi

发明人： Toshio Maki ,  Masao Kuramitsu ,  Kaoru Yamanoi

IPC分类号： B21K1/30 ,  B21C23/03 ,  B21K1/76

CPC分类号： B21K1/30 ,  Y10T29/49474

摘要： A cup-shaped raw workpiece having a bottom panel and a cylindrically-shaped circumferential panel is positioned facing downwardly on a movable lower punch having a forming gear profile. The lower punch is provided in a die having an orifice portion which together with the gear profile defines an orifice. A resilient mechanism resists downward movement of the lower punch. An upper punch is lowered to hold the bottom panel of the workpiece against the lower punch and pushes the workpiece to extrusion form the inner surface thereof through the orifice. An escape groove for excess metal can be provided in the bottom inside corner of the workpiece at the juncture of the circumferential panel and the bottom panel. The lower punch can be provided with an upwardly extending protrusion near the outer circumferential edge of the upper end surface thereof which has an outer chamfered circumferential edge.

摘要翻译： 具有底板和圆柱形周面板的杯状原料工件面向下定位在具有成形齿轮轮廓的可动下冲头上。 下冲头设置在具有孔部分的模具中，孔部分与齿轮轮廓一起形成孔口。 弹性机构抵抗下冲头的向下运动。 上冲头下降以将工件的底板保持抵靠下冲头，并通过孔口将工件推向其内表面。 在周面板和底板的接合处，可以在工件的底部内角设置用于多余金属的排出槽。 下冲头可以在其上端表面的外周边缘附近设置有向上延伸的突出部，其具有外倒角的圆周边缘。

公开(公告)号：US4484464A

公开(公告)日：1984-11-27

申请号：US322403

申请日：1981-11-18

申请人： Tetsuo Nihei ,  Toshio Maki ,  Kazuyoshi Sakuma

发明人： Tetsuo Nihei ,  Toshio Maki ,  Kazuyoshi Sakuma

IPC分类号： B21J5/08 ,  B21J9/08 ,  B21D22/00 ,  B21D31/00

CPC分类号： B21J9/08 ,  B21J5/08

摘要： An electrical upsetting method for upsetting a cylindrical metal material, which is durable against wear and tear due to high temperature as well as vigorous friction under heavy pressure during the upsetting work, wherein a space gap is provided between the outer peripheral surface of the workpiece and the inner peripheral surface of the shaping die to prevent the die from direct heat from the workpiece generated by electric conduction across the electrodes, or wherein a space gap is provided between the outer peripheral surface of the anvil electrode and the inner peripheral surface of the shaping die, and an inert gas is filled in the space gap to protect the die from oxidation due to its exposure to the external atmosphere, or air, as well as to maintain the die in a cooled condition by the inert gas.The present invention also proposes an improved electrical upsetting device provided with the inert gas feeding device which supplies such inert gas through the communicating grooves into the space gap defined between the anvil electrode and the shaping die to prevent the die from wear and tear due to its oxidation through exposure to the external atmosphere, thereby securing long service life of the shaping die.

摘要翻译： 一种用于镦锻圆柱形金属材料的电镦锻方法，其在镦锻工作期间由于高温以及在重压下的剧烈摩擦而耐磨损和耐磨，其中在工件的外周表面和 成形模具的内周面，以防止模具通过电极间的导电产生的来自工件的直接热量，或者在砧座电极的外周面与成形用的内周面之间设置有间隙 并且惰性气体填充在间隙中以保护模具由于其暴露于外部大气或空气而被氧化，并且通过惰性气体将模具保持在冷却状态。 本发明还提出一种改进的电气镦锻装置，其具有惰性气体供给装置，其通过连通槽将这种惰性气体提供到限定在砧座电极和成型模具之间的空间间隙中，以防止模具由于其而引起磨损 通过暴露于外部气氛进行氧化，从而确保成型模具的长使用寿命。

公开(公告)号：US4939829A

公开(公告)日：1990-07-10

申请号：US218248

申请日：1988-07-13

申请人： Toshio Maki ,  Chiyoshi Miura ,  Michitoshi Kono

发明人： Toshio Maki ,  Chiyoshi Miura ,  Michitoshi Kono

IPC分类号： B21K1/30 ,  B21D53/28

CPC分类号： B21K1/30 ,  Y10T29/49474

摘要： A gear is manufactured by heating a blank up to a warm working temperature range, upsetting and piercing the blank through warm f=orging, forming gear teeth on the blank through warm extrusion to produce an intermediate blank which is substantially of a gear shape, and then finishing the gear teeth accurately through cold sizing. The gear can be manufactured highly accurately with a good yield without requiring other intermediate processes such as normalizing and shot blasting.

摘要翻译： 通过将坯料加热到温暖的工作温度范围来制造齿轮，通过温暖的f =滚动镦锻和刺穿坯料，通过热挤压在坯料上形成齿轮齿以产生基本上为齿轮形状的中间坯料，以及 然后通过冷定径精确地完成齿轮齿。 齿轮可以高精度地制造，而且不需要诸如正火和喷丸之类的其它中间工艺，而且产量高。