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公开(公告)号:US20100130518A1
公开(公告)日:2010-05-27
申请号:US12520247
申请日:2007-12-18
申请人: Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
发明人: Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
IPC分类号: A61K31/519 , C07D471/04 , A61P35/00 , A61P37/02 , A61P11/06
CPC分类号: C07D471/04
摘要: Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于MEK(I):其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08420816B2
公开(公告)日:2013-04-16
申请号:US12796583
申请日:2010-06-08
IPC分类号: C07D471/12
CPC分类号: A61K31/541 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D471/16
摘要: Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.
摘要翻译: 公开了式I中的JAK抑制剂,其中在说明书中定义了G1,R1,R2,R3,R4,R5,R6和R7。 还公开了含有化合物的化合物,制备该化合物的方法和材料的药物组合物,试剂盒和制品,以及使用该化合物治疗涉及免疫系统和炎症的疾病,病症和病症的方法,包括类风湿性关节炎,血液学 恶性肿瘤,上皮癌(即癌)以及与JAK有关的其他疾病,病症或病症。
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公开(公告)号:US20080255160A1
公开(公告)日:2008-10-16
申请号:US11958999
申请日:2007-12-18
申请人: Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
发明人: Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
IPC分类号: A61K31/519 , C07D487/02 , C12N9/99 , A61P35/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00
CPC分类号: C07D471/04
摘要: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于MEK:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08022057B2
公开(公告)日:2011-09-20
申请号:US12267353
申请日:2008-11-07
申请人: Qing Dong , Toufike Kanouni , Michael B. Wallace
发明人: Qing Dong , Toufike Kanouni , Michael B. Wallace
IPC分类号: C07D471/04 , C07D513/04 , C07D498/04 , A61K31/437 , A61K31/4375 , A61P35/04 , C12N9/99
CPC分类号: C07D471/04 , C07D498/04 , C07D513/04
摘要: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于MEK:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20110136780A1
公开(公告)日:2011-06-09
申请号:US12796583
申请日:2010-06-08
IPC分类号: A61K31/4375 , C07D471/16 , A61K31/506 , A61K31/541 , A61K31/5377 , A61K31/496 , A61P37/08 , A61P17/00 , A61P11/06 , A61P19/02 , A61P25/00 , A61P17/06 , A61P11/00 , A61K31/519
CPC分类号: A61K31/541 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D471/16
摘要: Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.
摘要翻译: 公开了式I中的JAK抑制剂,其中在说明书中定义了G1,R1,R2,R3,R4,R5,R6和R7。 还公开了含有化合物的化合物,制备该化合物的方法和材料的药物组合物,试剂盒和制品,以及使用该化合物治疗涉及免疫系统和炎症的疾病,病症和病症的方法,包括类风湿性关节炎,血液学 恶性肿瘤,上皮癌(即癌)以及与JAK有关的其他疾病,病症或病症。
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公开(公告)号:US20090124595A1
公开(公告)日:2009-05-14
申请号:US12267353
申请日:2008-11-07
申请人: MarK Adams , Qing Dong , Toufike Kanouni , Stephen W. Kaldor , Nicholas Scorah , Michael B. Wallace
发明人: MarK Adams , Qing Dong , Toufike Kanouni , Stephen W. Kaldor , Nicholas Scorah , Michael B. Wallace
IPC分类号: C07D471/04 , A61K31/437 , A61K31/4375 , C07D513/04 , C07D498/04 , A61P35/04 , C12N9/99
CPC分类号: C07D471/04 , C07D498/04 , C07D513/04
摘要: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于MEK:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20070173488A1
公开(公告)日:2007-07-26
申请号:US11560460
申请日:2006-11-16
申请人: Pierre-Yves Bounaud , Stephanie Hopkins , Elizabeth Jefferson , Mark Wilson , Melissa Wong , Toufike Kanouni
发明人: Pierre-Yves Bounaud , Stephanie Hopkins , Elizabeth Jefferson , Mark Wilson , Melissa Wong , Toufike Kanouni
IPC分类号: A61K31/55 , A61K31/454 , A61K31/43 , C07D487/02
CPC分类号: C07D513/04
摘要: The present invention provides pyrazolothiazole kinase modulators, methods of treating certain disease states, such as cancer, and pharmaceutical composition thereof.
摘要翻译: 本发明提供吡唑并噻唑激酶调节剂,治疗某些疾病状态如癌症的方法及其药物组合物。
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