公开(公告)号：US20110045517A1

公开(公告)日：2011-02-24

申请号：US12741761

申请日：2008-11-06

Applicant: Tricia L Derringer ,  Matthew J Shaw ,  Rodney S Black ,  Trevor Petrel ,  Fred Moore ,  Laurence Slivon ,  David N Clark ,  Tom Danison

Inventor： Tricia L Derringer ,  Matthew J Shaw ,  Rodney S Black ,  Trevor Petrel ,  Fred Moore ,  Laurence Slivon ,  David N Clark ,  Tom Danison

IPC: C12Q1/46 ,  C12M1/34

CPC classification number: G01N21/78 ,  C12Q1/46 ,  G01N21/25

Abstract: A toxic material detection apparatus includes a sample collection portion including a sample inlet and a sample concentrator adapted to concentrate an environmental sample on a substrate. A sample distributing system transfers portions of the substrate to a color sensor and an ion mobility spectrometer for simultaneously analysis and toxin detection, particularly cholinesterase inhibitor detection. Optionally, a portion of the substrate may be directed to an archive for possible analysis at a later time. Reagents utilized include the enzyme acetylcholinesterase (AChE), and the reactants acetylthiocholine iodide (ATCI) and 5,5′-dithio-bis-(2-nitrobenzoic acid) (DTB). A data management unit provides for near-real-time analysis of the samples in under 5 minutes. Simultaneous “hits” by both analysis methods indicate the presence of a cholinesterase inhibitor.

Abstract translation: 有毒物质检测装置包括样品收集部分，其包括样品入口和适于将环境样品集中在基底上的样品浓缩器。 样品分配系统将基底的一部分转移到颜色传感器和离子迁移谱仪上，用于同时分析和毒素检测，特别是胆碱酯酶抑制剂检测。 可选地，可以将衬底的一部分定向到档案，以便在稍后的时间进行可能的分析。 使用的试剂包括乙酰胆碱酯酶（AChE）和乙酰硫胆碱碘化物（ATCI）和5,5'-二硫代双 - （2-硝基苯甲酸）（DTB）的反应物。 数据管理单元提供在5分钟内对样品的近实时分析。 两种分析方法的同时“命中”表明胆碱酯酶抑制剂的存在。