公开(公告)号：US09491933B2

公开(公告)日：2016-11-15

申请号：US12810202

申请日：2008-12-25

申请人： Nobuo Kubota ,  Tsuyoshi Shimamura ,  Saori Nagasaka

发明人： Nobuo Kubota ,  Tsuyoshi Shimamura ,  Saori Nagasaka

IPC分类号： A61K48/00 ,  A01K67/00 ,  C12Q1/02 ,  C12Q1/18

CPC分类号： A01K67/00 ,  A01K2207/10 ,  A01K2227/107 ,  A01K2267/0337 ,  C12Q1/025 ,  C12Q1/18

摘要： The invention can produce an infected nail of an animal and an infected animal model in which the nail plate and nail bed of the nail are sufficiently infected with a superficial fungus which were difficult to be produced in the past, and provides an evaluation method useful for development of a therapeutic agent for intractable infectious diseases such as tinea unguium using the nail and the infected animal model. For producing the infected nail of an animal and the infected animal model infected with a superficial fungus, an immunosuppressive component is administered to an animal in advance to decrease immunocompetence, and then, a superficial fungus is inoculated into the animal, whereby the infected nail of an animal and the infected animal model reflecting clinical manifestation in which the nail plate and nail bed of the nail are sufficiently infected with the superficial fungus can be produced with good reproducibility in a short period of time.

摘要翻译： 本发明可以产生感染的动物指甲和感染的动物模型，其中钉子的甲板和甲板被过去难以产生的浅表真菌充分感染，并且提供了用于 使用指甲和感染动物模型开发难治性感染性疾病如癣菌的治疗剂。 为了产生受感染的动物指甲和感染表皮真菌的受感染动物模型，预先向动物施用免疫抑制成分以降低免疫能力，然后将表面真菌接种到动物中，由此将受感染的指甲 可以在短时间内以良好的再现性产生反映临床表现的动物和感染的动物模型，其中甲板的指甲板和甲床被表面真菌充分感染。

公开(公告)号：US20100275277A1

公开(公告)日：2010-10-28

申请号：US12810202

申请日：2008-12-25

申请人： Nobuo Kubota ,  Tsuyoshi Shimamura ,  Saori Nagasaka

发明人： Nobuo Kubota ,  Tsuyoshi Shimamura ,  Saori Nagasaka

IPC分类号： A01K67/00 ,  C12Q1/18

CPC分类号： A01K67/00 ,  A01K2207/10 ,  A01K2227/107 ,  A01K2267/0337 ,  C12Q1/025 ,  C12Q1/18

摘要： The invention can produce an infected nail of an animal and an infected animal model in which the nail plate and nail bed of the nail are sufficiently infected with a superficial fungus which were difficult to be produced in the past, and provides an evaluation method useful for development of a therapeutic agent for intractable infectious diseases such as tinea unguium using the nail and the infected animal model. For producing the infected nail of an animal and the infected animal model infected with a superficial fungus, an immunosuppressive component is administered to an animal in advance to decrease immunocompetence, and then, a superficial fungus is inoculated into the animal, whereby the infected nail of an animal and the infected animal model reflecting clinical manifestation in which the nail plate and nail bed of the nail are sufficiently infected with the superficial fungus can be produced with good reproducibility in a short period of time.

摘要翻译： 本发明可以产生感染的动物指甲和感染的动物模型，其中钉子的甲板和甲板被过去难以产生的浅表真菌充分感染，并且提供了用于 使用指甲和感染动物模型开发难治性感染性疾病如癣菌的治疗剂。 为了产生受感染的动物指甲和感染表皮真菌的受感染动物模型，预先向动物施用免疫抑制成分以降低免疫能力，然后将表面真菌接种到动物中，由此将受感染的指甲 可以在短时间内以良好的再现性产生反映临床表现的动物和感染的动物模型，其中甲板的指甲板和甲床被表面真菌充分感染。