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公开(公告)号：US10753941B2
公开(公告)日：2020-08-25
申请号：US14342074
申请日：2012-09-03
申请人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
发明人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
摘要： The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
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2.发明申请Biocompatible Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes and Methods of Using the Same for In Vitro and In Vivo Imaging 审中-公开具有聚集诱导的排放特性作为荧光生物探针的生物相容纳米颗粒及其在体外和体内成像中的使用方法公开(公告)号：US20140328764A1
公开(公告)日：2014-11-06
申请号：US14342074
申请日：2012-09-03
申请人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
发明人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
IPC分类号： G01N33/58 , A61K49/00 , G01N33/574 , C12Q1/37
CPC分类号： G01N33/582 , A61K49/0021 , A61K49/0054 , A61K49/0093 , C09K11/06 , C12Q1/37 , G01N33/574 , G01N2333/96466
摘要： The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
摘要翻译： 荧光生物探针的发展包括显示聚集诱导发射（AIE）性质的有机荧光化合物，其生产方法及其在体外和体内生物成像中的实际应用。
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3.发明授权Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin 有权用于监测和阻滞胰岛素淀粉样纤颤的水溶性AIE发光体公开(公告)号：US08679738B2
公开(公告)日：2014-03-25
申请号：US13359514
申请日：2012-01-27
申请人： Benzhong Tang , Yuning Hong , Sijie Chen , Ryan Tsz Kin Kwok
发明人： Benzhong Tang , Yuning Hong , Sijie Chen , Ryan Tsz Kin Kwok
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/543
CPC分类号： G01N21/6428 , G01N33/542 , G01N2021/6432 , G01N2021/7786 , G01N2333/4709 , G01N2333/62
摘要： The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.
摘要翻译： 目前描述的主题涉及表现出聚集诱导发射的水溶性共轭多烯化合物及其衍生物，以及任何水分散性，荧光，聚合物微粒，纳米颗粒和/或药物组合物，其包含水溶性共轭 多烯化合物和/或其衍生物。 还提供制备和使用目前描述的主题的化合物，衍生物和颗粒的方法。 目前描述的水溶性共轭多烯化合物可用作检测生物大分子，在制造传感器中，用于体外和体内监测和阻滞淀粉样蛋白原纤维形成以及开发抗癌药物的生物探针。
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4.发明申请WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN 有权用于监测和延缓胰岛素的淀粉样纤维化的水溶性铝发光公开(公告)号：US20120172296A1
公开(公告)日：2012-07-05
申请号：US13359514
申请日：2012-01-27
申请人： Benzhong TANG , Yuning HONG , Sijie CHEN , Ryan Tsz Kin KWOK
发明人： Benzhong TANG , Yuning HONG , Sijie CHEN , Ryan Tsz Kin KWOK
CPC分类号： G01N21/6428 , G01N33/542 , G01N2021/6432 , G01N2021/7786 , G01N2333/4709 , G01N2333/62
摘要： The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.
摘要翻译： 目前描述的主题涉及表现出聚集诱导发射的水溶性共轭多烯化合物及其衍生物，以及任何水分散性，荧光，聚合物微粒，纳米颗粒和/或药物组合物，其包含水溶性共轭 多烯化合物和/或其衍生物。 还提供制备和使用目前描述的主题的化合物，衍生物和颗粒的方法。 目前描述的水溶性共轭多烯化合物可用作检测生物大分子，在制造传感器中，用于体外和体内监测和阻滞淀粉样蛋白原纤维形成以及开发抗癌药物的生物探针。
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