公开(公告)号：US4560556A

公开(公告)日：1985-12-24

申请号：US572750

申请日：1984-01-23

Applicant: Yoshio Kagitani ,  Kenji Tanaka ,  Yasuo Ueda ,  Yusei Shiraga ,  Tunetaka Nakajima ,  Takuji Doi ,  Takao Ohmura ,  Satoshi Funakoshi ,  Tadakazu Suyama

Inventor： Yoshio Kagitani ,  Kenji Tanaka ,  Yasuo Ueda ,  Yusei Shiraga ,  Tunetaka Nakajima ,  Takuji Doi ,  Takao Ohmura ,  Satoshi Funakoshi ,  Tadakazu Suyama

IPC: C07K14/705 ,  A61K31/40 ,  A61K31/43 ,  A61K31/545 ,  A61K31/70 ,  A61K38/00 ,  A61K38/16 ,  A61K38/22 ,  A61K47/48 ,  C07K14/435 ,  C07K14/78 ,  C07K19/00 ,  A61K35/16 ,  A61K37/04

CPC classification number: C07K14/78 ,  A61K47/48292 ,  A61K38/00 ,  Y10S530/829 ,  Y10S530/83

Abstract: Physiologically active substances such as antibiotics can preferentially be carried to a morbid part, for example, injured tissue and neoplastic cell proliferation site by administering its complex with fibronectin to repair the morbid part. The complex is prepared by the reaction between the physiologically active substance and the fibronectin with or without intervention of a protein cross-linking agent.

Abstract translation: 生理活性物质如抗生素可以优先通过给予其与纤连蛋白的复合物来修复病态部分而被携带到病态部分，例如损伤组织和肿瘤细胞增殖部位。 该复合物通过蛋白质交联剂的介导或不涉及生理活性物质与纤连蛋白之间的反应来制备。