公开(公告)号：US08497268B2

公开(公告)日：2013-07-30

申请号：US13483892

申请日：2012-05-30

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/495

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: Maleate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The salts are useful to provide blood levels of eszopiclone that are independent of fasting state.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。 这些盐可用于提供独立于空腹状态的依佐替克的血液水平。

公开(公告)号：US07500984B2

公开(公告)日：2009-03-10

申请号：US10939752

申请日：2004-09-13

Applicant: Richard C. Fuisz ,  Joseph M. Fuisz ,  Tushar Misra ,  Pradeep Sanghvi

Inventor： Richard C. Fuisz ,  Joseph M. Fuisz ,  Tushar Misra ,  Pradeep Sanghvi

IPC: A61J11/00 ,  A61J7/00 ,  A61J17/00

CPC classification number: A61J11/0015 ,  A61J7/0046 ,  A61J7/0053 ,  A61J11/0005 ,  A61J17/001 ,  A61J17/006

Abstract: The invention relates to a pacifier and nipple member for delivery of active ingredients into the oral cavity of an infant or patient. The pacifier includes a porous nipple member and a base member adapted to remain outside the oral cavity of the infant. The porous nipple member includes at least one reservoir or chamber therein for receiving a thin-film containing an active ingredient. The base member may be removably attached to the neck of the nipple member, or the nipple and base members may form a single unit. Reusable and disposable forms are disclosed.

Abstract translation: 本发明涉及一种用于将活性成分递送到婴儿或患者的口腔中的奶嘴和乳头构件。 奶嘴包括多孔乳头构件和适于保持在婴儿口腔外部的基部构件。 多孔乳头构件在其中包括至少一个储存器或室，用于接收含有活性成分的薄膜。 基部构件可以可移除地附接到乳头构件的颈部，或者乳头和基部构件可以形成单个单元。 公开了可重复使用和一次性形式。

公开(公告)号：US08497267B2

公开(公告)日：2013-07-30

申请号：US13470046

申请日：2012-05-11

Applicant: Richard Hsia ,  H. Scott Wilkinson ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： Richard Hsia ,  H. Scott Wilkinson ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: Besylate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

Abstract translation: -5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。

公开(公告)号：US08198277B2

公开(公告)日：2012-06-12

申请号：US12338899

申请日：2008-12-18

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousau

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousau

IPC: A61K31/495 ,  A61K31/4965

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: Pharmaceutical compositions of L malate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。

公开(公告)号：US20090209546A1

公开(公告)日：2009-08-20

申请号：US12338899

申请日：2008-12-18

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/4985 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: A novel L-malate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。

公开(公告)号：US20060058845A1

公开(公告)日：2006-03-16

申请号：US10939752

申请日：2004-09-13

Applicant: Richard Fuisz ,  Joseph Fuisz ,  Tushar Misra ,  Pradeep Sanghvi

Inventor： Richard Fuisz ,  Joseph Fuisz ,  Tushar Misra ,  Pradeep Sanghvi

IPC: A61J17/00

CPC classification number: A61J11/0015 ,  A61J7/0046 ,  A61J7/0053 ,  A61J11/0005 ,  A61J17/001 ,  A61J17/006

Abstract: The invention relates to a pacifier and nipple member for delivery of active ingredients into the oral cavity of an infant or patient. The pacifier includes a porous nipple member and a base member adapted to remain outside the oral cavity of the infant. The porous nipple member includes at least one reservoir or chamber therein for receiving a thin-film containing an active ingredient. The base member may be removably attached to the neck of the nipple member, or the nipple and base members may form a single unit. Reusable and disposable forms are disclosed.

公开(公告)号：US08541416B2

公开(公告)日：2013-09-24

申请号：US13470003

申请日：2012-05-11

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/495

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: L-malate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。

公开(公告)号：US20120238580A1

公开(公告)日：2012-09-20

申请号：US13483892

申请日：2012-05-30

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/4985 ,  A61P25/00

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。

公开(公告)号：US08268832B2

公开(公告)日：2012-09-18

申请号：US12338908

申请日：2008-12-18

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/4965

CPC classification number: C07D471/04

Abstract: Pharmaceutical compositions of maleate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b]pyrazine) are provided. The maleate salts are sleep agents useful in oral dosage forms.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,3- 4-b]吡嗪）。 马来酸盐是可用于口服剂型的睡眠剂。

公开(公告)号：US20110053945A1

公开(公告)日：2011-03-03

申请号：US12808025

申请日：2008-12-18

Applicant: H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas

IPC: A61K31/4985 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Novel mesylate, (R)-mandelate, succinate, citrate, fumarate, D-malate, D-tartrate, sulfate and L-tartrate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基）丙烯酸的新型甲磺酸酯，（R） - 扁桃酸酯，琥珀酸盐，柠檬酸盐，富马酸盐，D-苹果酸盐，D-酒石酸盐，硫酸盐和L-酒石酸盐 -1-哌嗪基）羰基氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪）。