公开(公告)号：US11939319B2

公开(公告)日：2024-03-26

申请号：US17058845

申请日：2019-06-18

申请人： UCB Pharma GmbH

发明人： Cecile Pegurier ,  Laurent Provins ,  Alvaro Cardenas ,  Marie Ledecq ,  Christa E. Mueller ,  Joerg Hockemeyer ,  Ali El-Tayeb ,  Nader Boshta ,  Mahmoud Rashed

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D471/04

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D471/04

摘要： The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.

公开(公告)号：US20230348384A1

公开(公告)日：2023-11-02

申请号：US18219417

申请日：2023-07-07

申请人： UCB Pharma GmbH

发明人： Christa E. MUELLER ,  Cécile PEGURIER ,  Michael Louis Robert DELIGNY ,  Ali EL-TAYEB ,  Joerg HOCKEMEYER ,  Marie LEDECQ ,  Joël MERCIER ,  Larurent PROVINS ,  Nader M. BOSHTA ,  Sanjay BHATTARAI ,  Vigneshwaran NAMASIVAYAM ,  Mario FUNKE ,  Lukas SCHWACH ,  Sabrina GOLLOS ,  Daniel VON LAUFENBERG ,  Anaïs BARRÉ

IPC分类号： C07D209/30 ,  C07D307/82 ,  C07D333/62 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D421/12 ,  C07D487/04 ,  C07D491/056

CPC分类号： C07D209/30 ,  C07D307/82 ,  C07D333/62 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D421/12 ,  C07D487/04 ,  C07D491/056

摘要： Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

公开(公告)号：US20180263921A1

公开(公告)日：2018-09-20

申请号：US15982744

申请日：2018-05-17

申请人： UCB Pharma GmbH

发明人： Hans-Michael WOLFF ,  Christoph ARTH ,  Luc QUERE ,  Walter MÜLLER

IPC分类号： A61K9/70 ,  A61K31/381

CPC分类号： A61K9/7069 ,  A61K9/7053 ,  A61K31/381

摘要： The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.

公开(公告)号：US20150104507A1

公开(公告)日：2015-04-16

申请号：US14519338

申请日：2014-10-21

申请人： UCB PHARMA GMBH

发明人： Willi CAWELLO ,  Martin Alexander SCHUBERT

IPC分类号： A61K31/165 ,  A61K9/16 ,  A61K9/48 ,  A61K9/28

CPC分类号： A61K9/0002 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2866 ,  A61K9/4891 ,  A61K9/50 ,  A61K31/165

摘要： A modified release formulation of lacosamide.

摘要翻译： 拉科酰胺的改性释放制剂。

公开(公告)号：US20140128377A1

公开(公告)日：2014-05-08

申请号：US14154409

申请日：2014-01-14

申请人： UCB Pharma GmbH

发明人： Thomas STÖHR

IPC分类号： A61K31/165 ,  A61K45/06 ,  A61K31/5513

CPC分类号： A61K31/165 ,  A61K31/55 ,  A61K31/5513 ,  A61K38/04 ,  A61K45/06 ,  G01N33/6893

摘要： The present invention is directed to the use of a class of peptide Compounds for prevention, alleviation or/and treatment of refractory Status epilepticus.

摘要翻译： 本发明涉及一类肽化合物用于预防，缓解或/和治疗难治性癫痫持续状态的用途。

公开(公告)号：US20140088168A1

公开(公告)日：2014-03-27

申请号：US14080440

申请日：2013-11-14

申请人： UCB Pharma GmbH

发明人： Thomas Stöhr

IPC分类号： A61K31/4015 ,  A61K31/165

CPC分类号： A61K31/19 ,  A61K31/165 ,  A61K31/195 ,  A61K31/35 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/53 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61K45/06 ,  B65D81/32

摘要： The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

摘要翻译： 本发明涉及一种药物组合物，其包含一类肽化合物的化合物（a）和用于预防，缓解或/和治疗癫痫发作的至少一种其它化合物（b）。

公开(公告)号：US12071404B2

公开(公告)日：2024-08-27

申请号：US17506331

申请日：2021-10-20

申请人： UCB Pharma GmbH

发明人： Christa E. Mueller ,  Cécile Pegurier ,  Michael Louis Robert Deligny ,  Ali El-Tayeb ,  Joerg Hockemeyer ,  Marie Ledecq ,  Joël Mercier ,  Laurent Provins ,  Nader M. Boshta ,  Sanjay Bhattarai ,  Vigneshwaran Namasivayam ,  Mario Funke ,  Lukas Schwach ,  Sabrina Gollos ,  Daniel Von Laufenberg ,  Anaïs Barré

IPC分类号： C07D209/30 ,  C07D307/82 ,  C07D333/62 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D421/12 ,  C07D487/04 ,  C07D491/056

CPC分类号： C07D209/30 ,  C07D307/82 ,  C07D333/62 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D421/12 ,  C07D487/04 ,  C07D491/056

摘要： Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

公开(公告)号：US20190314294A1

公开(公告)日：2019-10-17

申请号：US16420501

申请日：2019-05-23

申请人： UCB Pharma GmbH

发明人： Hans-Michael WOLFF ,  Christoph ARTH ,  Luc QUERE ,  Walter MÜLLER

IPC分类号： A61K9/70 ,  A61K31/381

摘要： The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a nom-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.

公开(公告)号：US10350174B2

公开(公告)日：2019-07-16

申请号：US15982744

申请日：2018-05-17

申请人： UCB Pharma GmbH

发明人： Hans-Michael Wolff ,  Christoph Arth ,  Luc Quere ,  Walter Müller

IPC分类号： A61K9/70 ,  A61K31/381

摘要： The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.

公开(公告)号：US20190008758A1

公开(公告)日：2019-01-10

申请号：US16027963

申请日：2018-07-05

申请人： UCB Pharma GmbH

发明人： Willi CAWELLO ,  Martin Alexander SCHUBERT

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/16 ,  A61K31/165

摘要： A modified release formulation of lacosamide suitable for once-daily administration.