公开(公告)号：US20130245783A1

公开(公告)日：2013-09-19

申请号：US13642362

申请日：2011-04-13

申请人： Ulrike Thull

发明人： Roger Thull

IPC分类号： A61L27/54

CPC分类号： A61L27/54 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404

摘要： The invention relates to an implant with a coating (23) which releases silver ions in the human body and as a result has antimicrobial action. According to the invention, a first surface component of the coating (23) is formed by an anode material (25). A second surface component of the coating (23) is formed by a cathode material (26). The cathode material is higher in the electrochemical voltage series than the anode material (25). The cathode material (26) and the anode material (25) are connected to one another in an electrically conductive manner. Together with the body electrolyte in the environment of the implant, the anode material (25) and the cathode material (26) form a multitude of local galvanic elements. The antimicrobial action of the coating (23) is improved as a result.

摘要翻译： 本发明涉及具有在人体内释放银离子的涂层（23）的植入物，因此具有抗微生物作用。 根据本发明，涂层（23）的第一表面部件由阳极材料（25）形成。 涂层（23）的第二表面部件由阴极材料（26）形成。 阴极材料的电化学电压系列比阳极材料（25）高。 阴极材料（26）和阳极材料（25）以导电方式彼此连接。 与植入物环境中的身体电解质一起，阳极材料（25）和阴极材料（26）形成多个局部电流元件。 因此，改善了涂层（23）的抗菌作用。

公开(公告)号：US09603972B2

公开(公告)日：2017-03-28

申请号：US13642362

申请日：2011-04-13

申请人： Ulrike Thull

发明人： Roger Thull

IPC分类号： A61F2/28 ,  A61L27/54 ,  A61L31/16

CPC分类号： A61L27/54 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404

摘要： The invention relates to an implant with a coating (23) which releases silver ions in the human body and as a result has antimicrobial action. According to the invention, a first surface component of the coating (23) is formed by an anode material (25). A second surface component of the coating (23) is formed by a cathode material (26). The cathode material is higher in the electrochemical voltage series than the anode material (25). The cathode material (26) and the anode material (25) are connected to one another in an electrically conductive manner. Together with the body electrolyte in the environment of the implant, the anode material (25) and the cathode material (26) form a multitude of local galvanic elements. The antimicrobial action of the coating (23) is improved as a result.

公开(公告)号：US20120083898A1

公开(公告)日：2012-04-05

申请号：US13253597

申请日：2011-10-05

申请人： Roger Thull ,  Ulrike Thull

发明人： Roger Thull ,  Ulrike Thull

IPC分类号： A61F2/28

摘要： In a prosthesis component of a joint endoprosthesis, the prosthesis component comprises a sliding surface that is designed to form a sliding joint with a counter sliding surface of another prosthesis component. The sliding surface may be formed by a sliding surface coating deposited on the body of the prosthesis component, wherein the sliding surface coating has an antimicrobial effect. The sliding surface coating is active against microorganisms in the area of the sliding joint.

摘要翻译： 在关节内假体的假体部件中，假体部件包括被设计成与另一个假体部件的反向滑动表面形成滑动关节的滑动表面。 滑动表面可以通过沉积在假体部件的主体上的滑动表面涂层形成，其中滑动表面涂层具有抗微生物效果。 滑动表面涂层在滑动关节区域对微生物有活性。

公开(公告)号：US20110272276A1

公开(公告)日：2011-11-10

申请号：US13088844

申请日：2011-04-18

申请人： Roger Thull ,  Ulrike Thull

发明人： Roger Thull ,  Ulrike Thull

IPC分类号： A61L27/54 ,  A61K9/00 ,  A61F2/02 ,  C25B9/06

CPC分类号： A61L27/54 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404

摘要： In a coated implant that releases silver ions in the human body and thereby has an antimicrobial effect, a first surface component of the coating is formed by an anode material. A second surface component of the coating is formed by a cathode material. The cathode material is higher in the electrochemical voltage sequence than the anode material. The cathode and the anode are connected with one another in an electrically conducting manner. Together with the body electrolyte in the vicinity of the implant the anode and the cathode material form a plurality of local galvanic elements.

摘要翻译： 在人体中释放银离子并由此具有抗菌作用的涂覆植入物中，涂层的第一表面组分由阳极材料形成。 涂层的第二表面组分由阴极材料形成。 阴极材料的电化学电压序列高于阳极材料。 阴极和阳极以导电方式彼此连接。 与植入物附近的身体电解质一起，阳极和阴极材料形成多个局部电流元件。

公开(公告)号：USRE45561E1

公开(公告)日：2015-06-16

申请号：US12985939

申请日：2011-01-06

申请人： Jake Barralet ,  Uwe Gbureck ,  Ulrike Thull

发明人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

IPC分类号： C04B12/02 ,  A61L24/02 ,  A61L24/00 ,  A61L27/42

CPC分类号： A61L24/0063 ,  A61L27/425 ,  C04B12/02

摘要： In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:—(i) a powdered component, said powdered component having an average particle size d50 of less than 15 μm, and (ii) a calcium phosphate based powder, said powder having an average particle size d50 greater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:—(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least −30 mV.

摘要翻译： 在第一方面，本发明公开了一种自定型磷酸钙水泥，其包括：（i）粉末状成分，所述粉末成分的平均粒径d50小于15μm，和（ii）磷酸钙基粉末， 所述粉末的平均粒度d50大于粉末成分的平均粒径，所述粉末成分和所述磷酸钙粉末以足够的量悬浮在含有溶解的ζ电位增加添加剂的水中，以将悬浮颗粒的ζ电位增加到 至少30mV，并且其中选择ζ电位增加添加剂与不含ζ电位增加添加剂的相同磷酸钙水泥的凝固pH相容。 在第二方面，本发明公开了一种搁置稳定的酸性凝固水泥粉末，其包括：（i）磷酸钙基粉末，和（ii）粉末状化合物，其在添加水以形成水泥浆料时延迟所述水泥 凝固反应或将所得悬浮颗粒的ζ电位提高至至少-30mV。