-
公开(公告)号:US20220273422A1
公开(公告)日:2022-09-01
申请号:US17631822
申请日:2020-07-30
发明人: Nicholas J. Manesis , Phihoa Tran-Hata , Alan Le , Khanh Nguyen
摘要: A corneal inlay device comprising a flat or flat-like base and a dome or droplet top. The corneal inlay can be used to treat, for example without limitation, presbyopia, while reducing or eliminating the risk of a patient developing corneal haze.
-
公开(公告)号:US11421313B2
公开(公告)日:2022-08-23
申请号:US12988834
申请日:2009-04-21
IPC分类号: B32B18/00 , C23C4/10 , C23C4/08 , A61L27/32 , B60B5/00 , A61L27/04 , A61L27/30 , A61L27/42 , C23C28/00 , C23C4/11
摘要: An article, at least a surface of the article being made of or containing an organic material, and a thermally sprayed layer of coating material on the surface.
-
公开(公告)号:US20220168473A1
公开(公告)日:2022-06-02
申请号:US17441404
申请日:2020-01-28
发明人: Adem AKSU , Frank REINAUER , Tobias WOLFRAM
摘要: The invention relates to an implant (1) with antimicrobial activity, comprising an implant mixture (IM) which has a base granular material (2) formed from a raw material mixture of biocompatible polymers and/or a ceramic granular material, the implant mixture (IM) also comprising at least one type of metal (3) in particle form which is suitable for releasing ions, the metal particles (3) being present in the form of silver particles and/or copper particles. The metal particles (3) are distributed in the volume of the implant (1). The invention also relates to a method for producing an implant (1) of said type.
-
公开(公告)号:US11344387B2
公开(公告)日:2022-05-31
申请号:US15401740
申请日:2017-01-09
申请人: BIOMET 3I, LLC
IPC分类号: A61C8/00 , A61B17/86 , A61L27/04 , A61L27/10 , A61L27/42 , A61L27/50 , B82Y30/00 , C23C22/02 , C23C26/00 , C23C30/00 , C23F1/00 , C23C24/08 , A61C13/00 , A61F2/30
摘要: A method of forming an implant to be implanted into living bone is disclosed. The method includes the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further includes forming a nanoscale roughened surface on the microscale roughened surface. The method further includes the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles have a material having a property that promotes osseointegration.
-
公开(公告)号:US11318230B2
公开(公告)日:2022-05-03
申请号:US15211986
申请日:2016-07-15
发明人: Samuel E. Lynch
IPC分类号: A61K38/18 , A61L27/12 , A61L27/24 , A61L27/56 , A61P19/08 , A61P19/04 , A61L27/54 , A61L27/40 , A61L27/58 , A61F2/28 , A61L27/22 , A61K9/00 , A61L27/02 , A61L27/42
摘要: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.
-
公开(公告)号:US11298213B2
公开(公告)日:2022-04-12
申请号:US16167950
申请日:2018-10-23
发明人: Jae Won Kim
IPC分类号: A61C8/00 , A61L24/00 , A61L27/34 , A61C13/083 , A61L27/42 , A61K6/58 , A61K6/818 , A61K6/824 , A61K6/802 , C04B41/45 , C08G77/58 , C09D183/14 , A61C5/73 , A61C13/00 , A61K6/50 , A61K6/56
摘要: A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.
-
公开(公告)号:US11278642B2
公开(公告)日:2022-03-22
申请号:US16823175
申请日:2020-03-18
发明人: Takao Hotokebuchi , Iwao Noda
摘要: To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.
-
公开(公告)号:US20210338895A1
公开(公告)日:2021-11-04
申请号:US17283555
申请日:2019-10-11
申请人: Access2Bone IP B.V.
摘要: The invention relates to a bioactive bone repair substrate comprising granules obtainable by or obtained from a set solid state mixture of a calcium phosphate based bone repair matrix and a bioactive material, preferably granules having an average diameter between 25 and 10,000 μm.
-
公开(公告)号:US11129774B2
公开(公告)日:2021-09-28
申请号:US16301773
申请日:2017-05-16
IPC分类号: A61K8/14 , A61K6/84 , A61L27/56 , C07C279/26 , C07D213/74 , C07C279/14 , A61K31/4425 , A61K31/155 , C07D213/20 , A61K31/444 , A61L27/54 , A61K9/00 , A61L27/42 , A61L27/30 , A61L27/44 , A61K9/14 , A61P1/02 , A01N25/08 , A61P31/04 , A61P31/02 , A61K9/51 , A61L27/32 , A61K31/785 , A61L27/12 , A61L27/10 , A61L27/02 , A01N43/40 , A01N47/44 , A61K31/20 , A61K6/20 , A61K6/35 , A61K6/40 , A61K6/54 , A61K6/71 , A61K6/74 , A61K6/76 , A61K6/80 , A61K6/86 , A61K6/802 , A61K6/849 , A61K6/853 , A61K6/864 , A61K6/871 , C08K3/22 , C08K3/32 , C08L33/12
摘要: A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.
-
10.
公开(公告)号:US11020508B2
公开(公告)日:2021-06-01
申请号:US16391195
申请日:2019-04-22
发明人: Houdin Dehnad , Paul E. Chirico , Bohdan Wolodymyr Chopko , John Barr , Robert Vincent McCormick , Julie Lucero , Jason A. Jegge
IPC分类号: A61L31/08 , A61L27/30 , A61L29/10 , A61L27/04 , A61L31/02 , A61L29/14 , A61L27/42 , A61K33/38 , A61K33/30 , A61K33/34 , A61K9/22 , A01N55/02 , A61L27/18 , A61L31/14 , C08L67/04 , A61L31/06 , A61L27/58 , A61L27/54 , A61L31/16 , A01N25/34 , A61L29/16 , A61K33/24
摘要: Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.
-
-
-
-
-
-
-
-
-