公开(公告)号：US20080113347A1

公开(公告)日：2008-05-15

申请号：US10596857

申请日：2004-12-28

申请人： Ainara Vallejo Illarramendi ,  Antonio Martinez Martinez ,  Usue Ariz Lopez de Castro ,  Lourdes Osaba Ortiz de Mendibil ,  Corina Junquera Sanchez-Vallejo ,  Simon Santa Cruz ,  Pedro Escudero Garcia de Galdeano ,  Jorge Ochoa Garay ,  Laureano Simon Buela ,  Carlos Matute Almau ,  Elena Alberdi Alfonso ,  Maria Victoria Sanchez Gomez ,  Gaskon Ibarretxe Bilbao ,  Estibaliz Etxebarria Galnares

发明人： Ainara Vallejo Illarramendi ,  Antonio Martinez Martinez ,  Usue Ariz Lopez de Castro ,  Lourdes Osaba Ortiz de Mendibil ,  Corina Junquera Sanchez-Vallejo ,  Simon Santa Cruz ,  Pedro Escudero Garcia de Galdeano ,  Jorge Ochoa Garay ,  Laureano Simon Buela ,  Carlos Matute Almau ,  Elena Alberdi Alfonso ,  Maria Victoria Sanchez Gomez ,  Gaskon Ibarretxe Bilbao ,  Estibaliz Etxebarria Galnares

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12N9/16 ,  C12Q1/42 ,  G01N33/5088 ,  G01N33/564 ,  G01N2800/285

摘要： The present invention refers to an in vitro method for detecting the presence of demyelinating diseases in an individual, for determining the stage or severity of said diseases in the individual, or for monitoring the effect of the therapy administered to an individual suffering said diseases; to the search, identification, development and evaluation of efficacy of compounds for therapy of said diseases for the purpose of developing new drugs; as well as to agents inhibiting DUSP6 protein expression and/or activity, and/or the effects of this expression. The methods and agents of the invention are preferably applied to multiple sclerosis.

摘要翻译： 本发明涉及用于检测个体中脱髓鞘疾病的存在的体外方法，用于确定个体中所述疾病的阶段或严重程度，或用于监测施用于患有所述疾病的个体的治疗效果; 用于研究，鉴定，开发和评估化合物治疗所述疾病以开发新药物的功效; 以及抑制DUSP6蛋白表达和/或活性的药剂，和/或该表达的作用。 本发明的方法和试剂优选应用于多发性硬化。