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1.发明授权STXBP1 overexpressing mouse and its uses in screening of treatments for neuropsychiatric illness 有权STXBP1过度表达小鼠及其在筛选神经精神疾病治疗中的应用公开(公告)号：US09267151B2
公开(公告)日：2016-02-23
申请号：US13059938
申请日：2009-08-18
申请人： Maria Jose Guerrero Martinez , Laureano Simon Buela , Marcel Ferrer-Alcon , Antonio Martinez Martinez , Jose Javier Meana , Luis Felipe Callado , Leyre Uriguen
发明人： Maria Jose Guerrero Martinez , Laureano Simon Buela , Marcel Ferrer-Alcon , Antonio Martinez Martinez , Jose Javier Meana , Luis Felipe Callado , Leyre Uriguen
IPC分类号： A01K67/027 , G01N33/00 , C12N15/85
CPC分类号： C12N15/8509 , A01K67/027 , A01K2217/052 , A01K2227/105 , A01K2267/03
摘要： A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.
摘要翻译： 具有编码STXBP1多肽的多核苷酸的非人转基因动物，所述多核苷酸可操作地连接至启动子，其中所述转基因动物在至少一个脑区域具有大于STXBP1多肽的野生型表达，以及相关载体 公开了生产转基因动物的方法，潜在治疗剂的体外和体内筛选方法以及治疗和诊断神经精神疾病的方法。
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公开(公告)号：US20080070253A1
公开(公告)日：2008-03-20
申请号：US11813646
申请日：2006-01-12
申请人： Laureano SIMON BUELA , Antonio MARTÍNEZ , Diego HERNÁNDEZ , Ellsa URIBE , Monica MARTÍNEZ , Marta OSEÑALDE , Lorena GARCÍA
发明人： Laureano SIMON BUELA , Antonio MARTÍNEZ , Diego HERNÁNDEZ , Ellsa URIBE , Monica MARTÍNEZ , Marta OSEÑALDE , Lorena GARCÍA
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q1/6883 , C12Q1/6888 , C12Q2600/156 , C12Q2600/16 , G06F19/00 , Y02A90/26
摘要： An in vitro method for genotyping genetic variations in a individual, and products for use in the method.
摘要翻译： 用于个体遗传变异的基因分型的体外方法和用于该方法的产品。
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公开(公告)号：US09702879B2
公开(公告)日：2017-07-11
申请号：US14237682
申请日：2012-08-08
申请人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
发明人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
IPC分类号： G01N33/573 , G01N33/574 , C07K16/18 , C07K16/30 , G01N33/50 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/57484 , C07K16/18 , C07K16/30 , C07K2317/33 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/6881 , G01N33/6887 , G01N2333/78 , G01N2800/56
摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.
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4.发明申请STXBP1 AS PSYCHIATRIC BIOMARKER IN MURINE MODEL SYSTEM AND THEIR USES 有权STXBP1作为MURINE模型系统中的PSYCHIATRIC BIOMARKER及其用途公开(公告)号：US20110268747A1
公开(公告)日：2011-11-03
申请号：US13059938
申请日：2009-08-18
申请人： Maria Jose Guerrero Martinez , Laureano Simon Buela , Marcel Ferrer-Alcon , Antonio Martinez Martinez , Jose Javier Meana , Luis Felipe Callado , Leyre Uriguen
发明人： Maria Jose Guerrero Martinez , Laureano Simon Buela , Marcel Ferrer-Alcon , Antonio Martinez Martinez , Jose Javier Meana , Luis Felipe Callado , Leyre Uriguen
IPC分类号： A61K39/395 , C12N15/85 , A61P25/18 , A61K31/713 , A61K31/7084 , A61P25/00 , A01K67/027 , A61K49/00
CPC分类号： C12N15/8509 , A01K67/027 , A01K2217/052 , A01K2227/105 , A01K2267/03
摘要： A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.
摘要翻译： 具有编码STXBP1多肽的多核苷酸的非人转基因动物，所述多核苷酸可操作地连接至启动子，其中所述转基因动物在至少一个脑区域具有大于STXBP1多肽的野生型表达，以及相关载体 公开了生产转基因动物的方法，潜在治疗剂的体外和体内筛选方法以及治疗和诊断神经精神疾病的方法。
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公开(公告)号：US20080274968A1
公开(公告)日：2008-11-06
申请号：US12104429
申请日：2008-04-16
申请人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
发明人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
CPC分类号： G01N33/57438 , C07K14/4703 , C07K14/705 , C07K14/71 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , Y10T436/143333
摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。
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6.发明申请METHODS AND PRODUCTS FOR IN VITRO DIAGNOSIS, IN VITRO PROGNOSIS AND THE DEVELOPMENT OF DRUGS AGAINST INVASIVE CARCINOMAS 有权用于体外诊断，体外预防的方法和产品以及针对入侵性癌症的药物的开发公开(公告)号：US20150362496A1
公开(公告)日：2015-12-17
申请号：US14237682
申请日：2012-08-08
申请人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
发明人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57484 , C07K16/18 , C07K16/30 , C07K2317/33 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/6881 , G01N33/6887 , G01N2333/78 , G01N2800/56
摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.
摘要翻译： 本发明涉及用于检测个体侵袭性癌的存在的体外方法和产品，用于确定和/或预测个体中所述癌的阶段和/或侵袭性，或用于监测施用的治疗的效果 对具有基于col11a1基因和proCOL11A1蛋白表达的癌症的个体。 本发明还涉及为了开发新的药用产品而寻求，鉴定，开发和评估化合物治疗所述癌症的功效。 本发明还涉及抑制proCOL11A1蛋白表达和/或活性的药剂和/或该表达的作用。
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公开(公告)号：US20130280171A1
公开(公告)日：2013-10-24
申请号：US13997069
申请日：2011-12-22
IPC分类号： A61K49/00 , A61K39/395
CPC分类号： G01N33/6893 , A61K39/3955 , A61K49/00 , C07K16/241 , C07K2317/21 , C07K2317/24 , G01N33/564 , G01N33/6854 , G01N33/9493 , G01N2333/525 , G01N2800/102 , G01N2800/24 , G01N2800/52 , G06F19/325 , G06F19/3468 , G16H20/17 , G16H40/20 , Y02A90/26
摘要： The invention relates to the field of personalized therapy and, in particular, to a method for classifying a patient suffering from rheumatoid arthritis as a responder or as a non-responder patient to a treatment based on a biological drug.
摘要翻译： 本发明涉及个性化治疗领域，特别涉及一种将类风湿性关节炎患者作为应答者或作为无反应者的患者分类为基于生物药物的治疗的方法。
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公开(公告)号：US07914990B2
公开(公告)日：2011-03-29
申请号：US11813646
申请日：2006-01-12
申请人： Laureano Simon Buela , Antonio Martinez Martinez , Diego Tejedor Hernandez , Elisa Jimenez Uribe , Monica Lopez Martinez , Marta Artieda Osenalde , Lorena Hernandez Garcia
发明人： Laureano Simon Buela , Antonio Martinez Martinez , Diego Tejedor Hernandez , Elisa Jimenez Uribe , Monica Lopez Martinez , Marta Artieda Osenalde , Lorena Hernandez Garcia
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q1/6883 , C12Q1/6888 , C12Q2600/156 , C12Q2600/16 , G06F19/00 , Y02A90/26
摘要： An in vitro method for genotyping genetic variations in a individual, and products for use in the method.
摘要翻译： 用于个体遗传变异的基因分型的体外方法和用于该方法的产品。
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9.发明申请Non-Invasive in Vitro Method to Detect Transitional Cell Carcinoma of the Bladder 审中-公开非侵入性体外检测膀胱移行细胞癌的方法公开(公告)号：US20090209431A1
公开(公告)日：2009-08-20
申请号：US12083446
申请日：2006-10-10
申请人： Ana Soloaga Villoch , Jose Luis Castrillo Diez , Inma Ramos Rodriguez , Kepa Escuredo Garcia-Galdeano , Antonio Martinez Martinez , Laureano Simon Buela
发明人： Ana Soloaga Villoch , Jose Luis Castrillo Diez , Inma Ramos Rodriguez , Kepa Escuredo Garcia-Galdeano , Antonio Martinez Martinez , Laureano Simon Buela
IPC分类号： C40B30/00 , G01N33/574 , G01N33/53 , C12Q1/02
CPC分类号： G01N33/57407 , G01N2800/52
摘要： The present invention refers to a non-invasive in vitro method to detect a transitional cell carcinoma of the bladder in an individual via urine analysis, to determine the stage or severity of this cancer in an individual or to monitor the effect of treatment administered to an individual suffering from this cancer.
摘要翻译： 本发明涉及通过尿液分析检测个体中膀胱移行细胞癌的非侵入性体外方法，以确定个体中该癌症的阶段或严重程度，或监测施用于患者的治疗效果 个体患有这种癌症。
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10.发明申请公开(公告)号：US20080113347A1
公开(公告)日：2008-05-15
申请号：US10596857
申请日：2004-12-28
申请人： Ainara Vallejo Illarramendi , Antonio Martinez Martinez , Usue Ariz Lopez de Castro , Lourdes Osaba Ortiz de Mendibil , Corina Junquera Sanchez-Vallejo , Simon Santa Cruz , Pedro Escudero Garcia de Galdeano , Jorge Ochoa Garay , Laureano Simon Buela , Carlos Matute Almau , Elena Alberdi Alfonso , Maria Victoria Sanchez Gomez , Gaskon Ibarretxe Bilbao , Estibaliz Etxebarria Galnares
发明人： Ainara Vallejo Illarramendi , Antonio Martinez Martinez , Usue Ariz Lopez de Castro , Lourdes Osaba Ortiz de Mendibil , Corina Junquera Sanchez-Vallejo , Simon Santa Cruz , Pedro Escudero Garcia de Galdeano , Jorge Ochoa Garay , Laureano Simon Buela , Carlos Matute Almau , Elena Alberdi Alfonso , Maria Victoria Sanchez Gomez , Gaskon Ibarretxe Bilbao , Estibaliz Etxebarria Galnares
CPC分类号： C12N9/16 , C12Q1/42 , G01N33/5088 , G01N33/564 , G01N2800/285
摘要： The present invention refers to an in vitro method for detecting the presence of demyelinating diseases in an individual, for determining the stage or severity of said diseases in the individual, or for monitoring the effect of the therapy administered to an individual suffering said diseases; to the search, identification, development and evaluation of efficacy of compounds for therapy of said diseases for the purpose of developing new drugs; as well as to agents inhibiting DUSP6 protein expression and/or activity, and/or the effects of this expression. The methods and agents of the invention are preferably applied to multiple sclerosis.
摘要翻译： 本发明涉及用于检测个体中脱髓鞘疾病的存在的体外方法，用于确定个体中所述疾病的阶段或严重程度，或用于监测施用于患有所述疾病的个体的治疗效果; 用于研究，鉴定，开发和评估化合物治疗所述疾病以开发新药物的功效; 以及抑制DUSP6蛋白表达和/或活性的药剂，和/或该表达的作用。 本发明的方法和试剂优选应用于多发性硬化。
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