公开(公告)号：US20050209565A1

公开(公告)日：2005-09-22

申请号：US11121291

申请日：2005-05-03

申请人： Vadim Yuzhakov ,  Faiz Sherman ,  Grover Owens ,  Vladimir Gartstein

发明人： Vadim Yuzhakov ,  Faiz Sherman ,  Grover Owens ,  Vladimir Gartstein

IPC分类号： A61M5/00 ,  A61M5/172 ,  A61M37/00 ,  A61N1/30

CPC分类号： B81C99/0085 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61N1/30 ,  B81B2201/055

摘要： Improved microneedle arrays are provided having a sufficiently large separation distance between each of the individual microneedles to ensure penetration of the skin while having a sufficiently small separation distance to provide high transdermal transport rates. A very useful range of separation distances between microneedles is in the range of 100-300 microns, and more preferably in the range of 100-200 microns. The outer diameter and microneedle length is also very important, and in combination with the separation distance will be crucial as to whether or not the microneedles will actually penetrate the stratum corneum of skin. For circular microneedles, a useful outer diameter range is from 20-100 microns, and more preferably in the range of 20-50 microns. For circular microneedles that do not have sharp edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 100-150 microns; for use with other biological fluids, a useful length is in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For circular microneedles having sharp side edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For solid microneedles having a star-shaped profile with sharp edges for its star-shaped blades, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns, while the radius of each of its blades is in the range of 10-50 microns, and more preferably in the range of 10-15 microns.

公开(公告)号：US20070161964A1

公开(公告)日：2007-07-12

申请号：US11328813

申请日：2006-01-10

申请人： Vadim Yuzhakov

发明人： Vadim Yuzhakov

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053

摘要： Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.

摘要翻译： 提供微针阵列和药物递送装置用于将药物制剂经皮递送给患者。 微针阵列器件包括具有孔阵列的基本上平面的衬底; 以及多个从平面基板以角度突出的微针，所述微针具有与基底一体地连接的基部，在基部的远侧的前端部和其间的主体部，其中每个微针具有基本上延伸的至少一个通道 从基部通过主体部分的至少一部分，通道沿着主体部分的至少一部分是开放的，并与衬底中的至少一个孔流体连通。 在优选实施例中，每个微针具有基本上矩形的横截面形状，并且通道对于微针的两个相对表面开放。

公开(公告)号：US20090099437A1

公开(公告)日：2009-04-16

申请号：US11870420

申请日：2007-10-11

申请人： Vadim Yuzhakov

发明人： Vadim Yuzhakov

IPC分类号： A61B5/157 ,  A61B5/151

CPC分类号： A61B5/1519 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150183 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150954 ,  A61B5/15109 ,  A61B5/157

摘要： A lancing device includes a housing for containing a lancet. A lancet driver couples with and moves the lancet within the housing. A skin interface cap has an opening defined therein to expose at least part of the lancet when moved by the driver. A sliding frame is coupled to the housing and to the skin interface cap. The frame being adjustable relative to the housing for accordingly adjusting said cap relative to the housing, whereby an extent to which the lancet is exposed through the opening is adjustable by adjusting the sliding frame.

摘要翻译： 采血装置包括用于容纳刺血针的壳体。 柳叶刀司机与房屋内的柳叶刀交配并移动。 皮肤接口帽具有限定在其中的开口，以在驾驶员移动时暴露至少部分刺血针。 滑动框架联接到壳体和皮肤界面盖。 所述框架相对于所述壳体是可调节的，以相对于所述壳体相应地调整所述盖，由此通过调节所述滑动框架来调节所述刺血针暴露通过所述开口的程度。