摘要:
Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for using them.
摘要:
The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.
摘要:
The present invention relates to a pharmaceutical composition comprising at least one compound of formula (I): or one of its pharmaceutically acceptable salts in which R1, R2 and R3 are independently a hydrogen or an R7—CO— group where R7 is an alkyl, alkene or alkyne group, linear, branched or cyclic, comprising 2 to 24 carbon atoms; R4 is a hydrogen atom or a mannosyl group substituted in position 6 by an R6 residue chosen from the group comprising a hydrogen atom and an R7—CO— group; and R5 is chosen from the group comprising a hydrogen atom, a mono-, di-, tri-, tetra- and penta-mannosyl; and the use of such a composition for manufacturing a medication intended for the prevention or treatment of an illness associated with the over-expression of TNF and/or IL-12 in a subject.