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1.发明授权Purified Arabinogalactan-Protein (AGP) composition useful in the treatment psoriasis and other disorders 失效纯化的阿拉伯半乳聚糖蛋白（AGP）组合物可用于治疗牛皮癣和其他疾病公开(公告)号：US07601368B2
公开(公告)日：2009-10-13
申请号：US10931814
申请日：2004-09-01
IPC分类号： A61K36/00
摘要： A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).
摘要翻译： 描述了通过选择性方法从Argemone mexicana植物的叶和/或茎分离的纯化的阿拉伯半乳聚糖蛋白（AGP）组合物。 还描述了从茄科植物的叶子和/或茎分离的纯化的阿拉伯半乳聚糖蛋白（AGP）组合物，其具有以下一种或多种作用：免疫抑制，淋巴增殖抑制，细胞因子调节如IL-2抑制，IFN γ抑制或IL-10诱导; 角质形成细胞增殖抑制，角质溶解活性和小鼠耳肿胀试验（MEST）中的抑制活性。
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2.发明申请公开(公告)号：US20090264341A1
公开(公告)日：2009-10-22
申请号：US12496924
申请日：2009-07-02
摘要： A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).
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3.发明申请Herbal extract comprising a mixture of saponins obtained from sapindus trifoliatus for anticonvulsant activity 审中-公开草药提取物包含从三叶皂甙获得的皂苷混合物，用于抗惊厥活性公开(公告)号：US20050249831A1
公开(公告)日：2005-11-10
申请号：US10525992
申请日：2003-08-27
IPC分类号： A61K20060101 , A61K31/704 , A61K35/00 , A61K36/77 , A61P20060101 , A61P25/06 , A61K35/78
CPC分类号： A61K36/77
摘要： A pharmaceutical composition comprising a herbal extract, comprising a mixture of saponins prepared from the pericarp of Sapindus trifoliatus, with binding affinities for the receptor sites viz. GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glutamate-NMDA glycine (strychnine insensitive) site and Sodium channel (site 2), having major mediatory role in anticonvulsant activity. A process for preparation of the herbal extract; isolation of six pure compounds from the mixture of saponins in the aqueous extract; and a pharmaceutical composition comprising the said extract in combination with pharmaceutically acceptable additives. A method of prophylactic treatment of migraine through anticonvulsant activity of the composition by its administration through intranasal route.
摘要翻译： 包含草药提取物的药物组合物，其包含由Sapindus trifoliatus的果皮制备的皂苷的混合物，对受体位点的结合亲和力。 GABA-A激动剂位点，谷氨酸 - AMPA位点，谷氨酸 - 红藻酸酯位点，谷氨酸-N NMDA激动位点，谷氨酸-N NMDA甘氨酸（士的宁不敏感）位点和钠通道（位点2），在抗惊厥活性中具有主要的介导作用。 制备草药提取物的方法 在水提取物中从皂甙混合物中分离出六种纯化合物; 以及包含所述提取物与药学上可接受的添加剂组合的药物组合物。 一种通过鼻内途径施用组合物的抗惊厥活性来预防性治疗偏头痛的方法。
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4.发明申请PURIFIED ARABINOGALACTAN-PROTEIN (AGP) COMPOSITION USEFUL IN THE TREATMENT PSORIASIS AND OTHER DISORDERS 审中-公开纯化的阿拉伯糖苷 - 蛋白质（AGP）组合物在治疗PSORIASIS和其他疾病中有用公开(公告)号：US20090270330A1
公开(公告)日：2009-10-29
申请号：US12497148
申请日：2009-07-02
摘要： A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).
摘要翻译： 描述了通过选择性方法从Argemone mexicana植物的叶和/或茎分离的纯化的阿拉伯半乳聚糖蛋白（AGP）组合物。 还描述了从茄科植物的叶子和/或茎分离的纯化的阿拉伯半乳聚糖蛋白（AGP）组合物，其具有以下一种或多种作用：免疫抑制，淋巴增殖抑制，细胞因子调节如IL-2抑制，IFN γ抑制或IL-10诱导; 角质形成细胞增殖抑制，角质溶解活性和小鼠耳肿胀试验（MEST）中的抑制活性。
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公开(公告)号：US20060045930A1
公开(公告)日：2006-03-02
申请号：US10931814
申请日：2004-09-01
摘要： A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).
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