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公开(公告)号：US20180327460A1
公开(公告)日：2018-11-15
申请号：US15906618
申请日：2018-02-27
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
CPC分类号： C07K14/20 , A61K38/00 , A61K39/02 , A61K39/0225 , A61K2039/55505 , A61K2039/6018 , A61K2039/6031 , C07K16/12 , C07K16/1207 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C12N5/06 , C12N15/70 , C12P21/00 , C12P21/02 , Y02A50/39 , Y02A50/396 , Y02A50/40 , Y02A50/401 , Y02A50/403
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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2.发明申请公开(公告)号：US20180326044A1
公开(公告)日：2018-11-15
申请号：US15768250
申请日：2016-10-13
申请人： Daniel C. CARTER
发明人： Daniel C. CARTER
IPC分类号： A61K39/15 , C07K14/44 , C07K14/005 , G01N33/569
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/6031 , A61K2039/64 , C07K14/005 , C07K14/44 , C07K2319/00 , C12N2720/12034 , C12N2740/16034 , C12N2760/16134 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071 , G01N33/56983 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392 , Y02A50/396 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/466
摘要： A fusion protein is provided which is based on a self-assembling gene-regulatory NSP10 protein and a protein or peptide capable of being fused to NSP10 without interfering with the assembly or aggregation of the resulting fusion protein. The disclosure also relates to any nanoparticle formed thereby whether complete or not, and methods for the use of the NSP10 fusion protein are also disclosed, including use as vaccines for any indication in humans or animals, therapeutic methods involving the use of the fusion proteins such as using the protein to targeted an antibody or receptor, such as for treating or diagnosing cancer, bio-sensors using the fusion protein, or the use of the fusion proteins in cell sorting or any imaging application.
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公开(公告)号：US20180280496A1
公开(公告)日：2018-10-04
申请号：US16009811
申请日：2018-06-15
申请人： ModernaTX, Inc.
发明人： GIUSEPPE CIARAMELLA , ERIC YI-CHUN HUANG , KAPIL BAHL , TAL ZAKS , SUNNY HIMANSU
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/51 , A61K9/5123 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/28 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/6056 , A61P31/12 , A61P31/14 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36034 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392 , Y02A50/51
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
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公开(公告)号：US20180271970A1
公开(公告)日：2018-09-27
申请号：US15767613
申请日：2016-10-21
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Kapil Bahl , Amy Espeseth , Dai Wang , Andrew J. Bett
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K31/7105 , A61K31/7115 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , C12N2760/18534 , Y02A50/39
摘要： The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
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公开(公告)号：US20180177859A1
公开(公告)日：2018-06-28
申请号：US15738240
申请日：2016-06-23
申请人： TechnoVax, Inc.
发明人： Jose M. GALARZA , Helene BOIGARD , George MARTIN
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , C12N9/50 , A61P31/14
CPC分类号： A61K39/12 , A61K39/145 , A61K2039/5258 , A61P31/14 , C07K14/005 , C12N7/00 , C12N9/506 , C12N2770/24023 , C12N2770/24034 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392 , Y02A50/394
摘要： Described herein are flavivirus virus-like particles (VLPs) that display on their surfaces antigenic flavivirus proteins. Also described are methods of making and using these VLPs.
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公开(公告)号：US09993543B2
公开(公告)日：2018-06-12
申请号：US14763947
申请日：2014-01-31
IPC分类号： A61K39/12 , C12N7/00 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/00
CPC分类号： A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/292 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55588 , C12N7/00 , C12N2710/10021 , C12N2710/10034 , C12N2710/24121 , C12N2710/24134 , C12N2720/12321 , C12N2720/12334 , C12N2740/16021 , C12N2740/16034 , C12N2760/16021 , C12N2760/16034 , C12N2770/20021 , C12N2770/20034 , C12N2770/24021 , C12N2770/24034 , C12N2770/24221 , C12N2770/24234 , C12N2770/32421 , C12N2770/32434 , C12N2770/32621 , C12N2770/32634 , C12N2795/10134 , C12N2795/14034 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.
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公开(公告)号：US09987355B2
公开(公告)日：2018-06-05
申请号：US13930953
申请日：2013-06-28
发明人： Steven G. Reed , Darrick Carter
IPC分类号： A61K39/39 , A61K9/107 , A61K39/00 , A61K39/35 , A61K45/06 , A61K39/008 , A61K39/04 , A61K39/145
CPC分类号： A61K39/39 , A61K9/107 , A61K39/0011 , A61K39/008 , A61K39/04 , A61K39/145 , A61K39/35 , A61K45/06 , A61K2039/55511 , A61K2039/55572 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/41 , Y02A50/491
摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
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公开(公告)号：US09926343B2
公开(公告)日：2018-03-27
申请号：US15267372
申请日：2016-09-16
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
IPC分类号： C07K14/20 , A61K39/02 , C12N5/07 , C12N15/70 , C07K16/12 , C12P21/02 , A61K39/00 , A61K38/00
CPC分类号： C07K14/20 , A61K38/00 , A61K39/02 , A61K39/0225 , A61K2039/55505 , A61K2039/6018 , A61K2039/6031 , C07K16/12 , C07K2319/00 , C12N5/06 , C12N15/70 , C12P21/02 , Y02A50/39 , Y02A50/396 , Y02A50/40 , Y02A50/401 , Y02A50/403
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US09884115B2
公开(公告)日：2018-02-06
申请号：US14873344
申请日：2015-10-02
申请人： Valneva Austria GmbH
发明人： Robert Schlegl , Michael Möhlen , Jürgen Wruss , Michael Weber
IPC分类号： A61K39/00 , A61K39/39 , C07D487/04 , C09K13/00 , H01L21/02 , A61K38/16 , A61K39/12 , C12N7/00 , A61K39/104
CPC分类号： A61K39/39 , A61K38/162 , A61K38/164 , A61K39/104 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C12N7/00 , C12N2770/24134 , Y02A50/39
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US20180000916A1
公开(公告)日：2018-01-04
申请号：US15703685
申请日：2017-09-13
发明人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Peter Klucar , Keiko Akagawa , Sandra Zurawski , SangKon OH
IPC分类号： A61K39/00 , C07K16/28 , C07K14/435
CPC分类号： A61K39/0011 , A61K2039/6056 , C07K14/435 , C07K16/2878 , C07K2319/00 , C07K2319/33 , C07K2319/91 , Y02A50/39 , Y02A50/466
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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