公开(公告)号：US20090263455A1

公开(公告)日：2009-10-22

申请号：US12105864

申请日：2008-04-18

申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

IPC分类号： A61K9/00 ,  A61P43/00

CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US20090263443A1

公开(公告)日：2009-10-22

申请号：US12408491

申请日：2009-03-20

申请人： Vanja King

发明人： Vanja King

IPC分类号： A61K9/00 ,  A61K31/4168 ,  A61P21/00 ,  A61K9/50

CPC分类号： A61K31/415

摘要： Effective treatments of spasticity and shivering that accompanies surgeries are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relax muscle fibers. This administration of clonidine or a pharmaceutically acceptable salt thereof is particularly useful following the surgery.

摘要翻译： 提供伴随手术的痉挛和发抖的有效治疗。 通过在目标部位处或附近施用有效量的可乐定，可以放松肌肉纤维。 可口定或其药学上可接受的盐的施用在手术后是特别有用的。

公开(公告)号：US20100106133A1

公开(公告)日：2010-04-29

申请号：US12260876

申请日：2008-10-29

申请人： Thomas A. Simonton ,  John M. Zanella ,  Vanja King

发明人： Thomas A. Simonton ,  John M. Zanella ,  Vanja King

IPC分类号： A61M5/31

CPC分类号： A61M37/0069 ,  A61M31/007

摘要： A drug cartridge is provided for delivering a drug pellet to a site beneath the skin of a patient, the drug cartridge comprising: two or more chambers, each chamber holding a drug pellet and having a proximal end and a distal end, the proximal end of the chamber having an opening to receive the drug pellet and a plunger, the distal end of the chamber having an opening for receiving the plunger and passage of the drug pellet, a bulking agent disposed within at least a portion of each chamber, wherein movement of the plunger to an extended position moves the drug pellet within the chamber of the cartridge out the distal end of the chamber and out of the drug cartridge. In some embodiments, instead or with the bulking agent pierceable superior and inferior covers are used to contain the drug pellets.

摘要翻译： 提供了药物盒，用于将药物丸粒输送到患者皮肤下方的部位，药物盒包括：两个或更多个腔室，每个腔室容纳药物丸粒并具有近端和远端，近端 所述腔室具有用于接收药物丸粒的开口和柱塞，所述腔室的远端具有用于接收柱塞和药物丸粒通道的开口，设置在每个腔室的至少一部分内的填充剂，其中， 柱塞到延伸位置将药筒内的药丸从药筒的远端移出药物盒。 在一些实施方案中，替代地或与填充剂可刺穿的上下盖用于容纳药物颗粒。

公开(公告)号：US09352137B2

公开(公告)日：2016-05-31

申请号：US12260876

申请日：2008-10-29

申请人： Thomas A. Simonton ,  John M. Zanella ,  Vanja King

发明人： Thomas A. Simonton ,  John M. Zanella ,  Vanja King

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： A61M37/0069 ,  A61M31/007

摘要： A drug cartridge is provided for delivering a drug pellet to a site beneath the skin of a patient, the drug cartridge comprising: two or more chambers, each chamber holding a drug pellet and having a proximal end and a distal end, the proximal end of the chamber having an opening to receive the drug pellet and a plunger, the distal end of the chamber having an opening for receiving the plunger and passage of the drug pellet, a bulking agent disposed within at least a portion of each chamber, wherein movement of the plunger to an extended position moves the drug pellet within the chamber of the cartridge out the distal end of the chamber and out of the drug cartridge. In some embodiments, instead or with the bulking agent pierceable superior and inferior covers are used to contain the drug pellets.

摘要翻译： 提供了药物盒，用于将药物丸粒输送到患者皮肤下方的部位，药物盒包括：两个或更多个腔室，每个腔室容纳药物丸粒并具有近端和远端，近端 所述腔室具有用于接收药物丸粒的开口和柱塞，所述腔室的远端具有用于接收柱塞和药物丸粒通道的开口，设置在每个腔室的至少一部分内的填充剂，其中， 柱塞到延伸位置将药筒内的药丸从药筒的远端移出药物盒。 在一些实施方案中，替代地或与填充剂可刺穿的上下盖用于容纳药物颗粒。

公开(公告)号：US08524267B2

公开(公告)日：2013-09-03

申请号：US12105864

申请日：2008-04-18

申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。