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    Dexamethasone formulations in a biodegradable material
    1.
    发明授权
    Dexamethasone formulations in a biodegradable material 有权
    地塞米松配方可生物降解材料

    公开(公告)号：US08524267B2

    公开(公告)日：2013-09-03

    申请号：US12105864

    申请日：2008-04-18

    申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    IPC分类号： A61F2/00 ,  A61K9/00

    CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Dexamethasone Formulations in a Bioegradable Material
    2.
    发明申请
    Dexamethasone Formulations in a Bioegradable Material 有权
    生物可降解材料中的地塞米松配方

    公开(公告)号：US20090263455A1

    公开(公告)日：2009-10-22

    申请号：US12105864

    申请日：2008-04-18

    申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    IPC分类号： A61K9/00 ,  A61P43/00

    CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
    3.
    发明申请
    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    生物可降解聚合物载体中的磺胺嘧啶配方

    公开(公告)号：US20090264478A1

    公开(公告)日：2009-10-22

    申请号：US12105375

    申请日：2008-04-18

    申请人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    发明人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/4402 ,  A61P29/00

    CPC分类号： A61K31/635 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Benzodiazepine formulation in a polyorthoester carrier
    4.
    发明授权
    Benzodiazepine formulation in a polyorthoester carrier 有权
    苯并二氮类制剂在聚原酸酯载体中

    公开(公告)号：US08940315B2

    公开(公告)日：2015-01-27

    申请号：US12426031

    申请日：2009-04-17

    申请人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    发明人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    IPC分类号： A61F13/00 ,  A01N43/62 ,  A61K31/55 ,  A61K31/197 ,  A61K9/00 ,  A61K47/34

    CPC分类号： A61K31/197 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。