公开(公告)号：US20240141353A1

公开(公告)日：2024-05-02

申请号：US18495687

申请日：2023-10-26

申请人： David M. EVANS ,  Vera SIMONENKO

发明人： David M. EVANS ,  Vera SIMONENKO

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00

CPC分类号： C12N15/1135 ,  A61K9/0019 ,  A61K9/5169 ,  A61P35/00 ,  C12N2310/14

摘要： siRNA molecules and pharmaceutical compositions containing siRNA molecules are provided for inhibiting expression of KRAS, RAF1 and mutant KRAS peptides or proteins. Methods of treatment of cancer are provided in which the pharmaceutical compositions are administered to a subject in need thereof. The cancer may be lung, colon, or pancreatic cancers, including non-small cell lung cancer (NSCLC). Combinations of siRNAs, packaged in nanoparticles with co-polymer carriers and delivered simultaneously to target cells, elicit an additive or synergistic effect to inhibit tumorous cell growth.

公开(公告)号：US08735567B2

公开(公告)日：2014-05-27

申请号：US12741645

申请日：2008-11-06

申请人： Patrick Y. Lu ,  Ling Li ,  Vera Simonenko

发明人： Patrick Y. Lu ,  Ling Li ,  Vera Simonenko

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

CPC分类号： A61K31/7105 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14

摘要： The present invention provides small interfering RNA (siRNA) molecules, compositions containing them, and methods of using them for improvement of skin scarless wound healing and other skin conditions, such as psoriasis and lupus-caused cutaneous lesions. The invention includes siRNA molecules and compositions containing them that inhibit the expression of one or more genes that promote pathological or undesired processes in wound healing and methods of using them.

摘要翻译： 本发明提供小干扰RNA（siRNA）分子，含有它们的组合物，以及使用它们用于改善皮肤无伤口伤口愈合和其它皮肤状况的方法，例如牛皮癣和狼疮引起的皮肤损伤。 本发明包括siRNA分子和含有它们的组合物，其抑制一种或多种促进伤口愈合中病理或不期望过程的基因的表达以及使用它们的方法。

公开(公告)号：US20130225655A1

公开(公告)日：2013-08-29

申请号：US13695073

申请日：2011-05-04

申请人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

发明人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

IPC分类号： A61K31/713 ,  C07H21/02 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2320/31 ,  C12Y114/99001

摘要： The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.

摘要翻译： 本发明提供了使用TGFbeta1和Cox-2抑制剂和TGFbeta1和Hoxb13抑制剂的组合的组合物和方法，用于治疗各种医疗状况，包括由创伤伤口和手术引起的皮肤灼伤，由于损伤和手术引起的角膜和视网膜的惊吓， 由于受伤和手术引起的内部器官惊吓，心脏病发作和手术引起的心脏组织惊厥，以及炎症和损伤引起的肺，肝，肾纤维化。 一个实例是使用siRNA抑制剂同时沉默TGFbeta1和Cox-2，导致显着较少的瘢痕形成。

公开(公告)号：US20100319074A1

公开(公告)日：2010-12-16

申请号：US12741645

申请日：2008-11-06

申请人： Patrick Y. Lu ,  Ling Li ,  Vera Simonenko

发明人： Patrick Y. Lu ,  Ling Li ,  Vera Simonenko

IPC分类号： A61K31/713 ,  C07H21/04 ,  A61P17/02 ,  A61K49/00

CPC分类号： A61K31/7105 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14

摘要： The present invention provides small interfering RNA (siRNA) molecules, compositions containing them, and methods of using them for improvement of skin scarless wound healing and other skin conditions, such as psoriasis and lupus-caused cutaneous lesions. The invention includes siRNA molecules and compositions containing them that inhibit the expression of one or more genes that promote pathological or undesired processes in wound healing and methods of using them.

摘要翻译： 本发明提供小干扰RNA（siRNA）分子，含有它们的组合物，以及使用它们用于改善皮肤无伤口伤口愈合和其它皮肤状况的方法，例如牛皮癣和狼疮引起的皮肤损伤。 本发明包括siRNA分子和含有它们的组合物，其抑制一种或多种促进伤口愈合中病理或不期望过程的基因的表达以及使用它们的方法。

公开(公告)号：US09642873B2

公开(公告)日：2017-05-09

申请号：US13695073

申请日：2011-05-04

申请人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

发明人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00 ,  A61K31/713 ,  C12N15/113 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2320/31 ,  C12Y114/99001

摘要： The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.