公开(公告)号：US20070092539A1

公开(公告)日：2007-04-26

申请号：US10564271

申请日：2003-07-10

申请人： Arturo Jimenez-Bayardo ,  Jose Tornero-Montano ,  Juan Quintana-Hau ,  Jaime Gonzalez ,  Leopoldo Baiza-Duran ,  Isabel Lopez-Sanchez ,  Victoria Sanchez-Castellanos

发明人： Arturo Jimenez-Bayardo ,  Jose Tornero-Montano ,  Juan Quintana-Hau ,  Jaime Gonzalez ,  Leopoldo Baiza-Duran ,  Isabel Lopez-Sanchez ,  Victoria Sanchez-Castellanos

IPC分类号： A61K9/00 ,  A61K31/54

CPC分类号： A61K9/0048 ,  A61K31/5415

摘要： A method of solubilizing a selective inhibitor active agent of cyclo-oxigenase-2 (COX-2), such as meloxicam, and a method of preparing an ophthalmic solution from the solubilized meloxicam for the treatment of distinct ocular affections are described. The invention also refers to an aqueous ophthalmic solution resulting from the method, said ophthalmic solution being characterized by its safety, innocuousness and efficiency in the treatment of the patient. The new aqueous ophthalmic solution is characterized in that its pharmaceutical value is found in the use of a vehicle of easy access which not only permits the solubility of meloxicam, but which also favors a greater patient tolerance to the treatment of distinct affections of the eye and the patient's post-surgical recovery.

摘要翻译： 描述了增溶环氧酶-2（COX-2）的选择性抑制剂活性剂如美洛昔康的方法，以及从溶解的美洛昔康制备眼用溶液以治疗不同的眼部感觉的方法。 本发明还涉及由该方法得到的眼用水溶液，所述眼用溶液的特征在于其对患者的治疗的安全性，无害性和效率。 新的眼用水溶液的特征在于其使用易于接近的载体的药物价值，其不仅允许美洛昔康的溶解度，而且还有利于更大的患者对治疗眼睛的不同影响的耐受性， 病人的手术后恢复。

公开(公告)号：US20060116428A1

公开(公告)日：2006-06-01

申请号：US10538815

申请日：2003-10-30

申请人： Arturo Jimenez-Bayardo ,  Leopoldo Baiza-Duran ,  Jaime Gonzalez ,  Victoria Sanchez-Castellanos ,  Miguel Padilla-Morones

发明人： Arturo Jimenez-Bayardo ,  Leopoldo Baiza-Duran ,  Jaime Gonzalez ,  Victoria Sanchez-Castellanos ,  Miguel Padilla-Morones

IPC分类号： A61K31/045

CPC分类号： A61K31/7004 ,  A61K9/0048 ,  A61K47/26

摘要： The present invention relates to an ophthalmic solution for the clarification of vitreous hemorrhages. More specifically, it relates to a pharmaceutically acceptable intraocular injectable solution, for the treatment of vitreous hemorrhages, whereby the reabsorption of such hemorrhage is encouraged. It enables the clarification of the vitreous hemorrhage in a significantly short period of time to allow for the timely diagnosis of the lesion and the repair of the damage the hemorrhage has caused to the vitreous body. The ophthalmic solution of the present invention is injected at least once into the vitreous humor of the patient in a therapeutically effective dose to obtain the desired result.

摘要翻译： 本发明涉及用于澄清玻璃体出血的眼用溶液。 更具体地说，本发明涉及用于治疗玻璃体出血的药学上可接受的眼内可注射溶液，由此鼓励这种出血的再吸收。 它可以在很短的时间内澄清玻璃体出血，以便及时诊断病变并修复出血对玻璃体造成的损伤。 将本发明的眼用溶液以治疗有效剂量至少一次注入患者的玻璃体液中以获得所需的结果。