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    Intravitreally-injectable solution for the treatment of vitreous hemorrhages
    1.
    发明申请
    Intravitreally-injectable solution for the treatment of vitreous hemorrhages 审中-公开
    用于治疗玻璃体出血的玻璃体内注射溶液

    公开(公告)号：US20060116428A1

    公开(公告)日：2006-06-01

    申请号：US10538815

    申请日：2003-10-30

    申请人： Arturo Jimenez-Bayardo ,  Leopoldo Baiza-Duran ,  Jaime Gonzalez ,  Victoria Sanchez-Castellanos ,  Miguel Padilla-Morones

    发明人： Arturo Jimenez-Bayardo ,  Leopoldo Baiza-Duran ,  Jaime Gonzalez ,  Victoria Sanchez-Castellanos ,  Miguel Padilla-Morones

    IPC分类号： A61K31/045

    CPC分类号： A61K31/7004 ,  A61K9/0048 ,  A61K47/26

    摘要： The present invention relates to an ophthalmic solution for the clarification of vitreous hemorrhages. More specifically, it relates to a pharmaceutically acceptable intraocular injectable solution, for the treatment of vitreous hemorrhages, whereby the reabsorption of such hemorrhage is encouraged. It enables the clarification of the vitreous hemorrhage in a significantly short period of time to allow for the timely diagnosis of the lesion and the repair of the damage the hemorrhage has caused to the vitreous body. The ophthalmic solution of the present invention is injected at least once into the vitreous humor of the patient in a therapeutically effective dose to obtain the desired result.

    摘要翻译： 本发明涉及用于澄清玻璃体出血的眼用溶液。 更具体地说，本发明涉及用于治疗玻璃体出血的药学上可接受的眼内可注射溶液，由此鼓励这种出血的再吸收。 它可以在很短的时间内澄清玻璃体出血，以便及时诊断病变并修复出血对玻璃体造成的损伤。 将本发明的眼用溶液以治疗有效剂量至少一次注入患者的玻璃体液中以获得所需的结果。

    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND THE RESULTING SOLUTION
    3.
    发明申请
    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND THE RESULTING SOLUTION 审中-公开
    制备拉伸光学溶液的方法和结果解决方案

    公开(公告)号：US20110105605A1

    公开(公告)日：2011-05-05

    申请号：US12983736

    申请日：2011-01-03

    申请人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    发明人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    IPC分类号： A61K31/215 ,  A61P27/02

    CPC分类号： A61K31/5575

    摘要： A method of solubilizing an analog active agent of the prostaglandin F2α, such as latanoprost, is described and a method of preparing an ophthalmic solution of the solubilized latanoprost for the treatment of distinct ocular ailments. This invention also refers to an ophthalmic aqueous solution resulting from the aforementioned method, which is characterized by its chemical stability at room temperature, its safety, and innocuousness and efficiency in the treatment of the patient. The new ophthalmic aqueous solution is distinguished because its pharmaceutical value is found in the handling of a vehicle of easy access that not only permits the solubility of latanoprost, but also promotes its chemical stability and a greater tolerance of the patient with its ophthalmic application for the treatment of the patient's ailment.

    摘要翻译： 对前列腺素F2α的类似物活性剂如拉坦前列素进行增溶的方法，以及制备溶解的拉坦前列素的眼用溶液的方法，用于治疗不同的眼部疾病。 本发明还涉及由上述方法得到的眼用水溶液，其特征在于其在室温下的化学稳定性，其安全性，以及对患者治疗的无害性和有效性。 新的眼用水溶液的特征在于其药物价值在易于接近的载体中被发现，其不仅允许拉坦前列素的溶解度，而且还促进其化学稳定性和对眼科应用的更大耐受性 治疗患者的疾病。

    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND RESULTING SOLUTION
    4.
    发明申请
    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND RESULTING SOLUTION 审中-公开
    制备拉伸光学溶液和溶液的方法

    公开(公告)号：US20110098355A1

    公开(公告)日：2011-04-28

    申请号：US12983751

    申请日：2011-01-03

    申请人： Arturo Jimenez-Bayardo ,  Jose Ruben TORNERO MONTANO ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    发明人： Arturo Jimenez-Bayardo ,  Jose Ruben TORNERO MONTANO ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    IPC分类号： A61K31/215 ,  A61P27/02

    CPC分类号： A61K31/5575

    摘要： A method of solubilizing an analog active agent of the prostaglandin F2α, such as latanoprost, is described and a method of preparing an ophthalmic solution of the solubilized latanoprost for the treatment of distinct ocular ailments. This invention also refers to an ophthalmic aqueous solution resulting from the aforementioned method, which is characterized by its chemical stability at room temperature, its safety, and innocuousness and efficiency in the treatment of the patient. The new ophthalmic aqueous solution is distinguished because its pharmaceutical value is found in the handling of a vehicle of easy access that not only permits the solubility of latanoprost, but also promotes its chemical stability and a greater tolerance of the patient with its ophthalmic application for the treatment of the patient's ailment.

    摘要翻译： 对前列腺素F2α的类似物活性剂如拉坦前列素进行增溶的方法，以及制备溶解的拉坦前列素的眼用溶液的方法，用于治疗不同的眼部疾病。 本发明还涉及由上述方法得到的眼用水溶液，其特征在于其在室温下的化学稳定性，其安全性，以及对患者治疗的无害性和有效性。 新的眼用水溶液的特征在于其药物价值在易于接近的载体中被发现，其不仅允许拉坦前列素的溶解度，而且还促进其化学稳定性和对眼科应用的更大耐受性 治疗患者的疾病。

    Method Of Preparing A Latanoprost Opthalmic Solution And The Resulting Solution
    5.
    发明申请
    Method Of Preparing A Latanoprost Opthalmic Solution And The Resulting Solution 有权
    制备拉坦前列素光学溶液的方法及其结果

    公开(公告)号：US20080021101A1

    公开(公告)日：2008-01-24

    申请号：US11597459

    申请日：2004-05-26

    申请人： Arturo Jimenez-Bayardo ,  Jose Tornero-Montano ,  Maria Lopez-Sanchez ,  Enrique Cruz-Olmos

    发明人： Arturo Jimenez-Bayardo ,  Jose Tornero-Montano ,  Maria Lopez-Sanchez ,  Enrique Cruz-Olmos

    IPC分类号： A61K31/215 ,  A61P27/02

    CPC分类号： A61K31/5575

    摘要： A method of solubilizing an analog active agent of the prostaglandin F2α, such as latanoprost, is described and a method of preparing an ophthalmic solution of the solubilized latanoprost for the treatment of distinct ocular ailments. This invention also refers to an ophthalmic aqueous solution resulting from the aforementioned method, which is characterized by its chemical stability at room temperature, its safety, and innocuousness and efficiency in the treatment of the patient. The new ophthalmic aqueous solution is distinguished because its pharmaceutical value is found in the handling of a vehicle of easy access that not only permits the solubility of latanoprost, but also promotes its chemical stability and a greater tolerance of the patient with its ophthalmic application for the treatment of the patient's ailment.

    摘要翻译： 描述了增溶前列腺素F2al的类似物活性剂如拉坦前列素的方法，以及制备用于治疗不同眼部疾病的溶解拉坦前列素的眼用溶液的方法。 本发明还涉及由上述方法得到的眼用水溶液，其特征在于其在室温下的化学稳定性，其安全性，以及对患者治疗的无害性和有效性。 新的眼用水溶液的特征在于其药物价值在易于接近的载体中被发现，其不仅允许拉坦前列素的溶解度，而且还促进其化学稳定性和对眼科应用的更大耐受性 治疗患者的疾病。

    Method of preparing a latanoprost opthalmic solution and the resulting solution
    6.
    发明授权
    Method of preparing a latanoprost opthalmic solution and the resulting solution 有权
    制备拉坦前列素眼药水的方法和所得溶液

    公开(公告)号：US08293789B2

    公开(公告)日：2012-10-23

    申请号：US11597459

    申请日：2004-05-26

    申请人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    发明人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    IPC分类号： A61K31/19 ,  A61K31/215

    CPC分类号： A61K31/5575

    摘要： A method of solubilizing an analog active agent of the prostaglandin F2α, such as latanoprost, is described and a method of preparing an ophthalmic solution of the solubilized latanoprost for the treatment of distinct ocular ailments. This invention also refers to an ophthalmic aqueous solution resulting from the aforementioned method, which is characterized by its chemical stability at room temperature, its safety, and innocuousness and efficiency in the treatment of the patient. The new ophthalmic aqueous solution is distinguished because its pharmaceutical value is found in the handling of a vehicle of easy access that not only permits the solubility of latanoprost, but also promotes its chemical stability and a greater tolerance of the patient with its ophthalmic application for the treatment of the patient's ailment.

    摘要翻译： 对前列腺素F2α的类似物活性剂如拉坦前列素进行增溶的方法，以及制备溶解的拉坦前列素的眼用溶液的方法，用于治疗不同的眼部疾病。 本发明还涉及由上述方法得到的眼用水溶液，其特征在于其在室温下的化学稳定性，其安全性，以及对患者治疗的无害性和有效性。 新的眼用水溶液的特征在于其药物价值在易于接近的载体中被发现，其不仅允许拉坦前列素的溶解度，而且还促进其化学稳定性和对眼科应用的更大耐受性 治疗患者的疾病。

    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND THE RESULTING SOLUTION
    8.
    发明申请
    METHOD OF PREPARING A LATANOPROST OPHTHALMIC SOLUTION AND THE RESULTING SOLUTION 审中-公开
    制备拉伸光学溶液的方法和结果解决方案

    公开(公告)号：US20110098354A1

    公开(公告)日：2011-04-28

    申请号：US12983721

    申请日：2011-01-03

    申请人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    发明人： Arturo Jimenez-Bayardo ,  Jose Ruben Tornero-Montaño ,  Maria Isabel Lopez-Sanchez ,  Enrique Cruz-Olmos

    IPC分类号： A61K31/215 ,  A61P27/02

    CPC分类号： A61K31/5575

    摘要： A method of solubilizing an analog active agent of the prostaglandin F2α, such as latanoprost, is described and a method of preparing an ophthalmic solution of the solubilized latanoprost for the treatment of distinct ocular ailments. This invention also refers to an ophthalmic aqueous solution resulting from the aforementioned method, which is characterized by its chemical stability at room temperature, its safety, and innocuousness and efficiency in the treatment of the patient. The new ophthalmic aqueous solution is distinguished because its pharmaceutical value is found in the handling of a vehicle of easy access that not only permits the solubility of latanoprost, but also promotes its chemical stability and, a greater tolerance of the patient with its ophthalmic application for the treatment of the patient's ailment.

    摘要翻译： 对前列腺素F2α的类似物活性剂如拉坦前列素进行增溶的方法，以及制备溶解的拉坦前列素的眼用溶液的方法，用于治疗不同的眼部疾病。 本发明还涉及由上述方法得到的眼用水溶液，其特征在于其在室温下的化学稳定性，其安全性，以及对患者治疗的无害性和有效性。 新的眼用水溶液的特征在于其药物价值在易于接近的载体的处理中发现，其不仅允许拉坦前列素的溶解度，而且还促进其化学稳定性，并且对患者的眼科应用具有更大的耐受性 治疗患者的疾病。