公开(公告)号：US20070238776A1

公开(公告)日：2007-10-11

申请号：US10592880

申请日：2002-07-25

申请人： Braj Lohray ,  Vidya Lohray ,  Vijay Barot ,  Saurin Raval ,  Preeti Raval ,  Sujay Basu

发明人： Braj Lohray ,  Vidya Lohray ,  Vijay Barot ,  Saurin Raval ,  Preeti Raval ,  Sujay Basu

IPC分类号： A61K31/40 ,  C07D207/325

CPC分类号： C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D207/36 ,  C07D207/48 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  G06F3/14 ,  G06F3/1438 ,  G09G5/363 ,  G09G2360/122

摘要： The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel substituted pyrrole compounds of the general formula (I), their analogs, their derivatives, their polymorphs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The invention also relates to the process for preparing such compounds, a composition containing such a compound and the use of such a compound and composition in medicine. The compounds lower triglyceride levels in blood and may be useful in the treatment of obesity, hyperlipidaemia, hypercholesteremia, syndrome X and diabetes.

摘要翻译： 本发明涉及新的取代吡咯化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型取代吡咯化合物，其类似物，其衍生物，其多晶型物，其互变异构形式，其药学上可接受的盐，其药学上可接受的溶剂合物及其含有它们的药物组合物。 本发明还涉及制备这种化合物的方法，含有这种化合物的组合物以及这种化合物和组合物在医药中的用途。 该化合物降低血液中的甘油三酯水平，并且可用于治疗肥胖，高脂血症，高胆固醇血症，综合征X和糖尿病。