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    THYROID RECEPTOR LIGANDS
    1.
    发明申请
    THYROID RECEPTOR LIGANDS 审中-公开
    甲状腺受体配体

    公开(公告)号：US20110301200A1

    公开(公告)日：2011-12-08

    申请号：US13126167

    申请日：2009-10-22

    申请人： Saurin Raval ,  Preeti Raval

    发明人： Saurin Raval ,  Preeti Raval

    IPC分类号： A61K31/4453 ,  C07D295/26 ,  A61P3/04 ,  A61K31/40 ,  C07C317/46 ,  A61P3/06 ,  C07C251/60 ,  A61K31/197

    CPC分类号： C07C251/60 ,  C07C311/29 ,  C07C317/22 ,  C07C2601/14 ,  C07C2602/42 ,  C07D207/48 ,  C07D211/96

    摘要： The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及作为甲状腺受体配体并且优选甲状腺激素受体β（TR-β）选择性的通式（I）的新型化合物。 此外，本发明涉及制备这些化合物的方法，它们的互变异构形式，涉及其合成的新中间体，其药学上可接受的盐，使用这些化合物的方法和含有它们的药物组合物。

    Novel Pyrroles Having Hypolipidemic Hypocholesteremic Activities, Process for Their Preparation and Pharmaceutical Compositions Containing Them and Their Use in Medicine
    3.
    发明申请
    Novel Pyrroles Having Hypolipidemic Hypocholesteremic Activities, Process for Their Preparation and Pharmaceutical Compositions Containing Them and Their Use in Medicine 有权
    具有低脂血症低胆固醇活性的新型吡咯，其制备方法和含有它们在医学中的应用的药物组合物

    公开(公告)号：US20070238776A1

    公开(公告)日：2007-10-11

    申请号：US10592880

    申请日：2002-07-25

    申请人： Braj Lohray ,  Vidya Lohray ,  Vijay Barot ,  Saurin Raval ,  Preeti Raval ,  Sujay Basu

    发明人： Braj Lohray ,  Vidya Lohray ,  Vijay Barot ,  Saurin Raval ,  Preeti Raval ,  Sujay Basu

    IPC分类号： A61K31/40 ,  C07D207/325

    CPC分类号： C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D207/36 ,  C07D207/48 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  G06F3/14 ,  G06F3/1438 ,  G09G5/363 ,  G09G2360/122

    摘要： The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel substituted pyrrole compounds of the general formula (I), their analogs, their derivatives, their polymorphs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The invention also relates to the process for preparing such compounds, a composition containing such a compound and the use of such a compound and composition in medicine. The compounds lower triglyceride levels in blood and may be useful in the treatment of obesity, hyperlipidaemia, hypercholesteremia, syndrome X and diabetes.

    摘要翻译： 本发明涉及新的取代吡咯化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型取代吡咯化合物，其类似物，其衍生物，其多晶型物，其互变异构形式，其药学上可接受的盐，其药学上可接受的溶剂合物及其含有它们的药物组合物。 本发明还涉及制备这种化合物的方法，含有这种化合物的组合物以及这种化合物和组合物在医药中的用途。 该化合物降低血液中的甘油三酯水平，并且可用于治疗肥胖，高脂血症，高胆固醇血症，综合征X和糖尿病。