公开(公告)号：US20190167822A1

公开(公告)日：2019-06-06

申请号：US16302565

申请日：2017-05-19

申请人： Manzoor KOYAKUTTY ,  Vijay Harish SOMASUNDARAM ,  Anusha ASHOKAN ,  Shantikumar NAIR ,  AMRITA VISHWA VIDYAPEETHAM

发明人： Manzoor KOYAKUTTY ,  Vijay Harish SOMASUNDARAM ,  Anusha ASHOKAN ,  Shantikumar NAIR

IPC分类号： A61K51/12 ,  A61K51/04 ,  A61P35/00

摘要： The invention discloses non-iodinated radiopaque microbeads that may be used in image guided embolization in a subject ailing with tumor. The non-iodinated radiopaque microbeads include a ceramic material doped with a CT contrast agent or a MRI contrast agent or both. The doped ceramic is blended with a polymer and the blend is electrosprayed to form the radiopaque microbeads. Further the radiopaque microbeads are radiolabeled with a radioactive isotope. Methods of synthesis of the radiopaque microspheres are also disclosed. The non-iodinated radiopaque microbeads with radiolabeling are capable of rendering an imageable computed tomography (CT) contrast or magnetic resonance imaging (MRI) contrast when administered in a subject. Also the microspheres are biodegradable and hence the treatment could be repeated in case of recurrence of the tumor in the subject.