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公开(公告)号：US11981111B2
公开(公告)日：2024-05-14
申请号：US17404733
申请日：2021-08-17
CPC分类号： B32B3/18 , B32B1/00 , B32B3/26 , B32B3/30 , B32B7/022 , B32B2307/546 , Y10T428/2457
摘要： An auxetic member for load bearing structures has a section including a plurality of structural units, and a top layer provided at a top end of the section and a bottom layer provided at a bottom end of the section. The structural units includes ribs with parallel surfaces and ribs with re-entrant surfaces and the ribs with parallel surfaces of the structural units are oriented at an angle α relative to a horizontal plane, the structural unit including a void enclosed by the ribs with parallel surfaces and ribs with re-entrant surfaces. The member is characterized in that the void of the structural units is filled with a packing material for improving load bearing capacity.
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2.发明公开公开(公告)号：US20240108573A1
公开(公告)日：2024-04-04
申请号：US18108542
申请日：2023-02-10
CPC分类号： A61K9/0043 , A61K9/1277 , A61K31/4166 , A61K47/10 , A61K47/12 , A61K47/28 , A61P25/08 , B82Y5/00
摘要： The present invention discloses a formulation comprising nano lipid carrier encapsulated active pharmaceutical ingredient suitable for rapid delivery of said active pharmaceutical ingredient to brain via intranasal olfactory route for managing acute epileptic emergency. The present invention also discloses a process for the preparation of said formulation and a method for treating acute epileptic emergency by administering therapeutically effective dose of said formulation.
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公开(公告)号：US11903961B2
公开(公告)日：2024-02-20
申请号：US17404688
申请日：2021-08-17
IPC分类号： A61K31/722 , A61K33/06 , A61P7/04 , A61L26/00 , C08J3/075
CPC分类号： A61K31/722 , A61K33/06 , A61L26/008 , A61L26/0023 , A61L26/0095 , A61P7/04 , C08J3/075 , A61L2400/04 , C08J2305/08
摘要： A composition and method of preparing the composition for rapid and effective hemostasis is provided. The composition includes a first agent to induce platelet plug formation, a second to induce vasoconstriction and a third agent for activation of coagulation cascade. The composition comprises of 0.01% to 5% of chitosan; 0.01% to 0.25% of potassium aluminum sulphate; and 0.01% to 0.25% calcium salt. The clotting time of the composition is in the range of 30s to 140s. A method of preparing the hemostatic composition is further disclosed. The composition is configured to control hemorrhage from oozing and pressured bleeding injury any site in human/animal body.
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公开(公告)号：US20210297445A1
公开(公告)日：2021-09-23
申请号：US16924468
申请日：2020-07-09
IPC分类号： H04L29/06
摘要： The invention discloses a method of reducing Denial of Service (DoS) attack in an Internet of Things (IoT) system. The method provides real time communication between a sender node and receiver node by multiplexing control channel (that uses voice traffic) and data channel (that uses internet protocol traffic). Further an IoT system is disclosed. The communication channel between the sender node and the receiver node is configured to divide into a control channel to perform a handshake to the receiver node and data channel to carry data. Also to prevent DoS attack ports are changed periodically using the control channel. The advantages include reduced DoS attack in the network, low memory footprint of less than 2 KB and the communication is real time. The system and method may be used in commercial IoT deployments like environmental monitoring, smart grid, smart cities and health care.
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公开(公告)号：US20200246441A1
公开(公告)日：2020-08-06
申请号：US16326536
申请日：2017-08-21
发明人： MANZOOR KOYAKUTTY , CLAUDE C.A. BERNARD , KRISHNAKUMAR N MENON , PRASHANT SADANANDAN , NATALIE L PAYNE , SHANTIKUMAR V NAIR
摘要： The present invention relates to compositions and methods for the treatment or prevention of autoimmune diseases such as demyelination disorders. The invention includes a composition comprising a peptide antigen comprising at least one beta (β) amino acid coupled to a carrier nano or microparticle of silica. In one embodiment the demyelination disorder is multiple sclerosis.
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公开(公告)号：US20190311444A1
公开(公告)日：2019-10-10
申请号：US16436059
申请日：2019-06-10
摘要： A smart distribution power grid (SDPG) system has at least one micro-grid, each comprising a set of intelligent entities and a set of external Smart Distribution Nodes, and a communication system enabling communication within the set of intelligent entities, forming an overlay communication network on the microgrid. The communication system is deployed on the micro-grid in a manner minimizing installation cost, communication cost and overall maintenance cost of the SDPG.
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7.发明申请公开(公告)号：US20190298695A1
公开(公告)日：2019-10-03
申请号：US16363977
申请日：2019-03-25
发明人： GOPI C. MOHAN , KRISHNAKUMAR N. MENON , JANE JOSE
IPC分类号： A61K31/416
摘要： The invention discloses compositions, methods and kits for use in treatment of diseases associated with CNS inflammation such as multiple sclerosis. The composition includes therapeutically effective amount of (1-H indazole-4yl-)methanol. Further, a method of inhibiting glial maturation factor beta (GMF-β) phosphorylation activity in cells is disclosed. The method of treating subjects includes administering a therapeutic effective amount of the composition. The administered composition suppresses the activity of the overexpressed GMF-β either by binding or blocking its phosphorylating sites and ameliorating the inflammatory condition. The disclosed compositions, methods and kits may be used in the treatment of diseases like multiple sclerosis, Alzheimer's disease, Parkinson's disease or cancer.
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8.发明申请公开(公告)号：US20190295192A1
公开(公告)日：2019-09-26
申请号：US16435985
申请日：2019-06-10
摘要： A system for optimal power utilization and supply strategy in a microgrid has a smart meter connected to a micro grid, at least one micro electricity manager connected to the smart meter, at least one wireless switch board connected to the micro electricity manager, and at least one intelligent device connected to said micro electricity manager. The system for optimal power utilization and supply strategy is configured as a cyber-physical system capable of dynamic energy management to minimize mismatch between electricity demand and generation.
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公开(公告)号：US10421728B2
公开(公告)日：2019-09-24
申请号：US16003304
申请日：2018-06-08
发明人： Prasanna Ramani
IPC分类号： C07D239/54
摘要： The disclosure in various embodiments is related to a peptide nucleic acid monomer (VI) and an improved process for preparation of PNA (VI) using nosyl-group containing starting material. The process includes reacting amino acid with a nosyl group. The nosyl protected amino acid is alkylated with 2-(Boc-amino)ethyl bromide to obtain an intermediate. The nosyl group of the obtained intermediate is removed to form a PNA backbone. The PNA backbone upon addition of a modified nucleobase results in the formation of a PNA monomer (VI). The obtained PNA monomer exhibits either chiral or achiral geometric properties.
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10.发明申请公开(公告)号：US20190167822A1
公开(公告)日：2019-06-06
申请号：US16302565
申请日：2017-05-19
申请人： Manzoor KOYAKUTTY , Vijay Harish SOMASUNDARAM , Anusha ASHOKAN , Shantikumar NAIR , AMRITA VISHWA VIDYAPEETHAM
摘要： The invention discloses non-iodinated radiopaque microbeads that may be used in image guided embolization in a subject ailing with tumor. The non-iodinated radiopaque microbeads include a ceramic material doped with a CT contrast agent or a MRI contrast agent or both. The doped ceramic is blended with a polymer and the blend is electrosprayed to form the radiopaque microbeads. Further the radiopaque microbeads are radiolabeled with a radioactive isotope. Methods of synthesis of the radiopaque microspheres are also disclosed. The non-iodinated radiopaque microbeads with radiolabeling are capable of rendering an imageable computed tomography (CT) contrast or magnetic resonance imaging (MRI) contrast when administered in a subject. Also the microspheres are biodegradable and hence the treatment could be repeated in case of recurrence of the tumor in the subject.
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