公开(公告)号：US20100010035A1

公开(公告)日：2010-01-14

申请号：US12224617

申请日：2007-03-01

Applicant: Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Tim Perkins ,  Christer Westerlund

Inventor： Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Tim Perkins ,  Christer Westerlund

IPC: A61K31/422 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/4439 ,  C07D471/04 ,  C07D413/14 ,  A61P9/12

CPC classification number: C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.

Abstract translation: 本发明涉及下式的新化合物：[化学式应在此插入。 请参见纸质文件]其中R1，R2，R3和R31如本文所述。 本发明还涉及其制备方法，以及新化合物与先前已知的试剂的组合。 本发明还涉及上述化合物和组合物在制备用于治疗不同种类的高血压，减轻不同种类的器官损伤，治疗或预防糖尿病肾病，治疗内皮素和血管紧张素介导的病症以及治疗 前列腺癌。

公开(公告)号：US07750020B2

公开(公告)日：2010-07-06

申请号：US11547046

申请日：2005-04-01

Applicant: Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

Inventor： Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

IPC: A61K31/437 ,  A61K31/429 ,  C07D513/04 ,  C07D31/4365

CPC classification number: C07D513/04

Abstract: The present invention provides compounds of the formula (I), which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, Type 2 diabetes and obesity.

Abstract translation: 本发明提供了作为葡萄糖激酶活性的激活剂的式（I）化合物，因此可用作治疗葡糖激酶介导的病症的治疗剂。 因此，式（I）化合物可用于预防和治疗葡萄糖耐量异常，2型糖尿病和肥胖症。

公开(公告)号：US20080103167A1

公开(公告)日：2008-05-01

申请号：US11547046

申请日：2005-04-01

Applicant: Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

Inventor： Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

IPC: A61K31/437 ,  A61K31/429 ,  C07D513/04 ,  A61K31/4365

CPC classification number: C07D513/04

Abstract: The present invention provides compounds of the formula (I), which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, Type 2 diabetes and obesity.

Abstract translation: 本发明提供了作为葡萄糖激酶活性的激活剂的式（I）化合物，因此可用作治疗葡糖激酶介导的病症的治疗剂。 因此，式（I）化合物可用于预防和治疗葡萄糖耐量异常，2型糖尿病和肥胖症。