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公开(公告)号：US07875592B2
公开(公告)日：2011-01-25
申请号：US10591577
申请日：2005-03-04
IPC分类号： A61K31/702 , C07H3/06
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译： 本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。
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公开(公告)号：US20110130354A1
公开(公告)日：2011-06-02
申请号：US12960145
申请日：2010-12-03
IPC分类号： A61K31/7034 , C07H11/00 , C07H15/08 , C07H15/18 , C07H15/26 , A61K31/7028 , A61K31/7056 , A61P35/00 , A61P35/04 , A61P29/00 , A61P7/02 , A61P3/00 , A61P31/00 , A61P9/00 , A61P19/02 , A61P25/00 , A61P11/06 , A61P9/10
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译： 本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。
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公开(公告)号：US20070185037A1
公开(公告)日：2007-08-09
申请号：US10591577
申请日：2005-03-04
申请人： Vito Ferro , Jon Fairweather , Tomislav Karoli , Ligong Liu
发明人： Vito Ferro , Jon Fairweather , Tomislav Karoli , Ligong Liu
IPC分类号： A61K31/702 , C07H3/06
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译： 本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。
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公开(公告)号：US08828952B2
公开(公告)日：2014-09-09
申请号：US12738552
申请日：2008-10-16
申请人： Vito Ferro , Tomislav Karoli , Ligong Liu , Paul Newton Handley , Kenneth David Johnstone , Norbert Wimmer , Edward Timothy Hammond
发明人： Vito Ferro , Tomislav Karoli , Ligong Liu , Paul Newton Handley , Kenneth David Johnstone , Norbert Wimmer , Edward Timothy Hammond
CPC分类号： C07J43/003 , C07H3/04 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/207 , C07H15/24 , C07H15/26 , C07H17/02 , C07J17/005 , C07J31/006 , C07J41/0088 , C07J41/0094
摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.
摘要翻译： 本发明涉及可用作硫酸乙酰肝素结合蛋白的抑制剂的新型化合物; 包含该化合物的组合物，以及该化合物及其组合物用于哺乳动物受试者的抗血管生成，抗转移，抗炎，抗微血管和/或抗血栓形成治疗的用途。
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公开(公告)号：US20110245196A1
公开(公告)日：2011-10-06
申请号：US12738552
申请日：2008-10-16
申请人： Vito Ferro , Karoli Tomislav , Liu Ligong , Handley Paul Newton , Johnstone Kenneth David , Norbert Wimmer , Hammond Edward Timothy
发明人： Vito Ferro , Karoli Tomislav , Liu Ligong , Handley Paul Newton , Johnstone Kenneth David , Norbert Wimmer , Hammond Edward Timothy
IPC分类号： A61K31/7016 , C07H13/02 , C07H13/00 , C07J31/00 , A61K31/7024 , A61K31/702 , A61P35/04 , A61P35/00 , A61P29/00 , A61P7/02 , A61P9/00 , A61P31/00 , A61P3/06
CPC分类号： C07J43/003 , C07H3/04 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/207 , C07H15/24 , C07H15/26 , C07H17/02 , C07J17/005 , C07J31/006 , C07J41/0088 , C07J41/0094
摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.
摘要翻译： 本发明涉及可用作硫酸乙酰肝素结合蛋白的抑制剂的新型化合物; 包含该化合物的组合物，以及该化合物及其组合物用于哺乳动物受试者的抗血管生成，抗转移，抗炎，抗微血管和/或抗血栓形成治疗的用途。
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公开(公告)号：US08173606B2
公开(公告)日：2012-05-08
申请号：US12960145
申请日：2010-12-03
IPC分类号： A61K31/7034 , A61K31/7028 , A61K31/7056 , C07H11/00 , C07H15/08 , C07H15/18
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译： 本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。
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