公开(公告)号：US10088476B2

公开(公告)日：2018-10-02

申请号：US15027921

申请日：2014-09-29

申请人： The Board of Trustees of the University of Illinois ,  Vytrace Corporation

发明人： Paul V. Braun ,  Gerald G. Cano ,  Chunjie Zhang

IPC分类号： G01N33/543 ,  G01N33/542 ,  G01N33/544 ,  G01N33/66 ,  A61B5/145

摘要： The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.