公开(公告)号：US10088476B2

公开(公告)日：2018-10-02

申请号：US15027921

申请日：2014-09-29

申请人： The Board of Trustees of the University of Illinois ,  Vytrace Corporation

发明人： Paul V. Braun ,  Gerald G. Cano ,  Chunjie Zhang

IPC分类号： G01N33/543 ,  G01N33/542 ,  G01N33/544 ,  G01N33/66 ,  A61B5/145

摘要： The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.

公开(公告)号：US20160252505A1

公开(公告)日：2016-09-01

申请号：US15027921

申请日：2014-09-29

申请人： Gerry G. CANO ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Paul V. Braun ,  Gerald G. Cano ,  Chunjie Zhang

IPC分类号： G01N33/543 ,  G01N33/542 ,  G01N33/544 ,  G01N33/66

CPC分类号： G01N33/54373 ,  A61B5/14532 ,  G01N33/542 ,  G01N33/544 ,  G01N33/66

摘要： The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.

摘要翻译： 本发明涉及水凝胶和有机凝胶传感器以及它们在连续分析物监测中的应用。 传感器可以包括水凝胶或有机凝胶基质。 提供了标准和反向设计。 在一个实施方案中，基质可以包括用于分析物（例如葡萄糖分析物）的分子识别剂和可与分子识别剂可逆结合的体积重置试剂。 分子识别剂和体积重置剂之间的可逆交联可以通过竞争性结合过程与分析物相互作用而改变基质的体积。 在各种实施方案中，本发明提供了一种基于水凝胶的葡萄糖传感器和用于连续葡萄糖监测的传感器。 葡萄糖传感器可以基于葡萄糖反应性水凝胶，其在生理条件下具有与葡萄糖浓度（例如约0.05-50mM）线性相关的体积。 因此，本发明提供了适用于临床环境的血糖监测器。