公开(公告)号：US08785477B2

公开(公告)日：2014-07-22

申请号：US13685454

申请日：2012-11-26

申请人： Peng Lu ,  Rui Zhang ,  Wansong Yu ,  Mingjie Zhu ,  Yilang Chen

发明人： Peng Lu ,  Rui Zhang ,  Wansong Yu ,  Mingjie Zhu ,  Yilang Chen

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.

摘要翻译： 提供了六氢吡咯并[3,4-b]吡咯衍生物，其制备方法和药物用途。 具体地，提供了由下式（I）表示的二肽基肽酶IV抑制剂。 这些化合物可用于治疗或预防与二肽基肽酶IV相关的疾病，如糖尿病，肥胖症和高脂血症。 提供式（I）化合物及其药学上可接受的盐，其药物组合物的制备方法及其在制备用于治疗或预防与二肽基肽酶IV相关的疾病的药物中的用途。

公开(公告)号：US20130178500A1

公开(公告)日：2013-07-11

申请号：US13685454

申请日：2012-11-26

申请人： Peng Lu ,  Rui Zhang ,  Wansong Yu ,  Mingjie Zhu ,  Yilang Chen

发明人： Peng Lu ,  Rui Zhang ,  Wansong Yu ,  Mingjie Zhu ,  Yilang Chen

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.

摘要翻译： 提供了六氢吡咯并[3,4-b]吡咯衍生物，其制备方法和药物用途。 具体地，提供了由下式（I）表示的二肽基肽酶IV抑制剂。 这些化合物可用于治疗或预防与二肽基肽酶IV相关的疾病，如糖尿病，肥胖症和高脂血症。 提供式（I）化合物及其药学上可接受的盐，其药物组合物的制备方法及其在制备用于治疗或预防与二肽基肽酶IV相关的疾病的药物中的用途。