公开(公告)号：US20120028827A1

公开(公告)日：2012-02-02

申请号：US13193472

申请日：2011-07-28

申请人： Wei-Chiao Chang ,  Chih-Hung Lee ,  Suh-Hang Juo ,  Wei-Chiao Chen ,  Hsin-Su Yu

发明人： Wei-Chiao Chang ,  Chih-Hung Lee ,  Suh-Hang Juo ,  Wei-Chiao Chen ,  Hsin-Su Yu

IPC分类号： C40B30/04 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.

摘要翻译： 本发明提供了一种用于确定受试者患有特应性皮炎的风险的方法，包括：获得受试者的生物样品; 检测生物样品中ORAI1基因（SEQ ID No .: 1）的30881位单核苷酸多态性rs12313273（C / T）的存在; 并确定受试者患有特应性皮炎的风险，其中单核苷酸多态性rs12313273（C / T）的C等位基因或基因型CC的存在表明受试者处于患有特应性皮炎的风险增加 。