公开(公告)号：US20090169482A1

公开(公告)日：2009-07-02

申请号：US11930417

申请日：2007-10-31

申请人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

发明人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

IPC分类号： A61K49/00

CPC分类号： A61K49/0032 ,  A61K49/0056 ,  A61K49/0093

摘要： A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

摘要翻译： 具有氧化物核心，共价连接到氧化物核心的生物相容性聚合物外壳的纳米颗粒成像探针，染料和将染料共价结合到探针上的可切割间隔物。 当间隔物被切割时，染料从探针中释放出来。 当染料与探针结合时，染料的排放物被淬灭，当染料从探针中释放出来时，染料的发射不被淬灭。 间隔物可以是例如肽。 氧化物核可以是例如氧化硅芯。

公开(公告)号：US20090098057A1

公开(公告)日：2009-04-16

申请号：US11872866

申请日：2007-10-16

申请人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

发明人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

IPC分类号： A61K49/00 ,  A61B5/00

CPC分类号： A61K49/0032 ,  A61K49/0056 ,  A61K49/0093

摘要： A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

公开(公告)号：US20080095699A1

公开(公告)日：2008-04-24

申请号：US11738558

申请日：2007-04-23

申请人： Shiying Zheng ,  Ruizheng Wang ,  Wenyi Che

发明人： Shiying Zheng ,  Ruizheng Wang ,  Wenyi Che

IPC分类号： A61K49/00 ,  A61K39/395 ,  A61K49/06 ,  A61K49/18 ,  A61K51/12 ,  A61K9/14

CPC分类号： A61K49/0093 ,  A61K49/0032 ,  A61K49/1881

摘要： The present invention relates to a nanoparticle comprising self-assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the self-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core.

摘要翻译： 本发明涉及包含自组装的交联的两亲性嵌段共聚物和至少一种固定化染料的纳米颗粒，其中所述自组装的交联的两亲性嵌段共聚物包含亲水嵌段和疏水嵌段，其中所述自组装交联 两亲性嵌段共聚物自组装形成包含疏水嵌段的纳米颗粒的核心，其中所述疏水嵌段衍生自至少一个侧链多官能交联的烷氧基硅烷或氨基硅烷部分，并且所述纳米颗粒的外部包含亲水嵌段 ，并且其中固定的染料固定在芯中。