公开(公告)号：US20130195755A1

公开(公告)日：2013-08-01

申请号：US13807348

申请日：2011-06-28

申请人： Elmar Poselt ,  Hauke Kloust ,  Horst Weller ,  Christian Schmidtke ,  Christian Fuhrmann ,  Sascha Kappen ,  Werner Pauer ,  Hans-Ulrich Moritz

发明人： Elmar Poselt ,  Hauke Kloust ,  Horst Weller ,  Christian Schmidtke ,  Christian Fuhrmann ,  Sascha Kappen ,  Werner Pauer ,  Hans-Ulrich Moritz

IPC分类号： A61K49/00 ,  C12Q1/00 ,  A61K51/12 ,  A61K9/51

CPC分类号： A61K49/0002 ,  A61K9/51 ,  A61K51/1265 ,  B01J13/18 ,  C12Q1/00

摘要： The field of the present invention relates to the stabilisation of nanoparticles in aqueous dispersion and, in particular, the stabilisation of nanoparticles by encapsulating the nanoparticles in a micellular combination. The field of the present invention further relates to a micellular combination of nanoparticles and a method of manufacture of the micellular combination and uses thereof. In a first aspect the present disclosure teaches a micellular combination that allows the stable dispersion of nanoparticles into aqueous environment. The micellular combination comprises at least one nanoparticle in a core of the micellular combination. A plurality of surfactants is co-assembled with a plurality of hydrophobic ligands on the surface of the nanoparticle in such a way that the hydrophilic part of the surfactant forms a hydrophilic shell around the core of the micellular combination.

摘要翻译： 本发明的领域涉及在水分散体中稳定纳米颗粒，特别涉及通过将纳米颗粒包封在胶束组合中来稳定纳米颗粒。 本发明的领域还涉及纳米颗粒的微胶囊组合和胶束组合的制造方法及其用途。 在第一方面，本公开内容教导了允许纳米颗粒稳定分散到水性环境中的微胶囊组合。 胶束组合包含胶束组合核心中的至少一个纳米颗粒。 多个表面活性剂与纳米颗粒表面上的多个疏水配体共组装，使得表面活性剂的亲水部分在胶束组合的核心周围形成亲水壳。