Constricted neck blister pack and apparatus and method for making the same
    2.
    发明授权
    Constricted neck blister pack and apparatus and method for making the same 有权
    颈缩泡罩包装及其制造方法

    公开(公告)号:US06588180B2

    公开(公告)日:2003-07-08

    申请号:US09775952

    申请日:2001-02-02

    IPC分类号: B65B4704

    CPC分类号: B65B47/04 B65D75/36

    摘要: A blister pack which confines the movement a dosage form in order to resist damage thereto during handling and transportation while permitting removal of the intact dosage form, and apparatus and methods for the same. In particular, the invention provides a blister pack wherein the blister includes a protruding region between the opening and the base, thereby producing a constricted area or “neck” in the blister. In a preferred embodiment, the protruding region comprises an inwardly directed annulus formed in the blister wall. Accordingly, vertical movement of the dosage form is confined as a result of the protruding region, thereby reducing the likelihood of damage to the dosage form caused by agitation of the blister pack. The invention is particularly useful in packaging frangible pharmaceutical dosage forms formed in situ within the blister, such as freeze dried dosage forms and rapidly dissolving oral dosage forms.

    摘要翻译: 一种泡罩包装,其将运动限制为剂型,以便在处理和运输期间抵抗其损伤,同时允许去除完整的剂型,以及用于其的装置和方法。 特别地,本发明提供一种泡罩包装,其中泡罩包括在开口和基部之间的突出区域,从而在泡罩中产生收缩区域或“颈部”。 在优选实施例中,突出区域包括形成在泡罩壁中的向内指向的环形空间。 因此,作为突出区域的结果限制了剂型的垂直移动,从而降低了由泡罩包装的搅动引起的剂型损伤的可能性。 本发明特别可用于包装在泡罩内原位形成的易碎药物剂型,例如冻干剂型和快速溶解口服剂型。